ID I3KU39_ORENI Unreviewed; 1192 AA.
AC I3KU39;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN Name=DCTN1 {ECO:0000313|Ensembl:ENSONIP00000024635.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024635.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000024635.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
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DR AlphaFoldDB; I3KU39; -.
DR STRING; 8128.ENSONIP00000044114; -.
DR Ensembl; ENSONIT00000024656.2; ENSONIP00000024635.2; ENSONIG00000019569.2.
DR GeneTree; ENSGT00940000155378; -.
DR HOGENOM; CLU_002523_0_0_1; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1170.10; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 2.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 31..73
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 82..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 169..499
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 880..971
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1013..1040
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1099..1126
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 120..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1192 AA; 132589 MW; 5E7EDD03E121D4E2 CRC64;
QSLRRGGRPV KVGSLVEVIG KGQRGTVAYI GTTLFASGKW VGVILDEAKG KNDGTVQGKR
YFTCEENHGI FVRQSQIQLV DDGADTTSPE TPEPGTGKVP KRGENAHTHP DGHICRSSLG
AASGSASASA GEMSSSEPST PAQTPLAAPV IPTLHSPGNP PAPIPSKEEE ALRNQVKDLE
EKLETLKMKR TEDKAKLKEL EKHKIQLEQL QEWKTKMQEQ QAELQKQLKE AKREAKEALE
AKEHYMEEMS DTADAIEMAT LDKEMAEERA ESLQLEVDSL KEKVDELTMD LEILKHEIEE
KGSDGAASSY HVKQLEEQNS RLKEALVRMR DLSASEKQEH VKLQKQMEKK NVELDSLRSQ
KEKLQEEMKA AEKTIDELKE QVDAALGAEE MVETLTERNL DLEEKVRELR ETVTDLEAIN
EMNDELQENA RETELELREM LDLGAARVRE AEKRVEAAQE TVADYQQTIK KYRELTAHLQ
EVNRELTSQQ EASAELQQQP PAEMFDFKIK FAETKAYAKA IEMELRKMEV GQANRHVSLL
TSFMPESFLR HGGDHDCILV LLLIPRLICK AELISKQAQE KFDLNENCVE RAGLKGALGE
QLSFAGGLVY SLSLLQATLH KYEQALSQCS VEVYKKIGSL YPEMSVHERS LDFLIDLLHK
DQLDETVNVE PFVSIFFHFT QSALDCMAVE VGRLRAFLHA GQEKADLAVL LKDLETSCSD
IRQFCKKIRR RMPGTDAPGI PAALSFGQQV SDTLSDCRKH LTWVVAVLQE VAAAGAQMMS
PLGEQEGLSA VKLEDVAFKA GEQIYGSQGA NPYEYLRQSC SIVIATMNKM ATAMQEGEYD
SEKPQNKNPP PVDVRAAALR AEITDAEGLG LKLEDRETVI KELKKSLKIK GEELSEANVR
LSLLEKKLDS SSKDADERVE KIQTRLDEAQ TLLKKKEKEF EETMDALQAD IDQLEAEKAE
LKQRINSQSK MTIDGLRGTG PSGIASIVTG MAGGVGSGSG VQVIDSPLLT QQIEAQRLCI
KHLKNENNRL KAEKMRAQLA SLPPLNVTKL PSKDGRPEVL SSALYRKTDQ LLETLLQMSA
NVKVVDITGK SPVTPGAQLL EQTARLQSLN DTLDRLKDEV AEHVVNLQPG ARVSSDFATF
PSTSFVKVKE EKQGDTVLVG RVMVPCPRGQ EQVHRLVLSQ SELRRVHSLL RT
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