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Database: UniProt
Entry: I3KUE7_ORENI
LinkDB: I3KUE7_ORENI
Original site: I3KUE7_ORENI 
ID   I3KUE7_ORENI            Unreviewed;      2253 AA.
AC   I3KUE7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024743.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000024743.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC       of calcium ions into excitable cells and are also involved in a variety
CC       of calcium-dependent processes, including muscle contraction, hormone
CC       or neurotransmitter release, gene expression, cell motility, cell
CC       division and cell death. This channel gives rise to T-type calcium
CC       currents. T-type calcium channels belong to the "low-voltage activated
CC       (LVA)" group and are strongly blocked by nickel and mibefradil. A
CC       particularity of this type of channels is an opening at quite negative
CC       potentials, and a voltage-dependent inactivation. T-type channels serve
CC       pacemaking functions in both central neurons and cardiac nodal cells
CC       and support calcium signaling in secretory cells and vascular smooth
CC       muscle. They may also be involved in the modulation of firing patterns
CC       of neurons which is important for information processing as well as in
CC       cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC       1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   Ensembl; ENSONIT00000024764.2; ENSONIP00000024743.2; ENSONIG00000019655.2.
DR   GeneTree; ENSGT00940000159664; -.
DR   HOGENOM; CLU_000540_2_0_1; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 4.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR043203; VGCC_Ca_Na.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF137; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW   ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM        107..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        777..795
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        807..828
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        898..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        974..997
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1004..1027
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1211..1229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1249..1270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1282..1300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1349..1368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1448..1471
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1547..1564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1584..1603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1682..1706
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1766..1787
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          115..431
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          776..1002
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          1209..1481
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          1547..1798
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          37..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          707..727
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1050..1158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1481..1502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2007..2034
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2176..2236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1787..1821
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        505..539
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1067..1120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2007..2029
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2222..2236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         380
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT   BINDING         956
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT   BINDING         1420
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ   SEQUENCE   2253 AA;  251295 MW;  530BD355D3DE569C CRC64;
     MAEDGGNLSG VPDAGASEGR SSLPRTFIRL NDLSGLGTGG GEHGEVSAVE PASPAPDGIS
     AAGEEMSASG GDSLPYPTLA PVVFFYLKQT TRPRSWCLKM VCNPYPFLFL LTQPSMLVIL
     LNCVTLGMFH PCEDINCDSE RCKILQDFDD FIFAFFAIEM VIKMVALGNF GKKCYLGDTW
     NRLDFFIVLA GMLEYSLNLQ NVSLSAVRTV RVLRPLRAIN RVPSMRILVT LLLDTLPMLG
     NVLLLCFFVF FIFGIVGVQL WSGLLRNRCF VEDNFSFPLS VERGKYYHTE NDDENPFICS
     QPRENGMRDC SSIPKLYEEG GLECTLDIDS YNSTDNTTCV NWNQYYTNCS AGLINPFKGA
     INFDNICYAW IAIFQVITLE GWVDIMYFVM DAHSFYNFIY FILLIIIGSF FMINLCLVVI
     ATQFSETKQR ESQLMKEQRV RFMSNASTLA SLSEPGSCYD ELLKYLVHII RKGAKQVAHI
     CRLLARRAGL HIAASPPATD IQRSHSQRRR RKTSRQGSVS VHHIMHHHHQ HHHHHYHLGN
     GSVRGGGSTR CLDSREIEAT SDMNLAILSS PAADSSSVCS VLNTNSGIAP GFFSLAPAPK
     SRAIKRNSVP FAAPGPKNYP TLQARALAES RRGSIAASTL TNINLNIPPM PQDRRPSSLV
     DPLSPTAQLS CQLSARDLST TSSAMDTAAL TLDPESCPYC AKALANESEG GTEGNETPGD
     SDSDGVYEFT QDLHHRDRRD SRQPKKKHRR LGKTAAKVVH FWRLVCDTFR KIVDSKYFGR
     GIMIAILINT LSMGIEYHEQ PEELTNALEI SNIVFTSLFS LEMLLKVLVY GPFGYIKNPY
     NIFDGIIVVI SVWEIVGQQG GGLSVLRTFR LMRVLKLVRF MPALQRQLVV LMKTMDNVAT
     FCMLLMLFIF IFSILGMHLF GCKFGSERDG DTLPDRKNFD SLLWAIVTVF QILTQEDWNK
     VLYNGMASTS PVAALYFIAL MTFGNYVLFN LLVAILVEGF QAEFINFTTV KCCFCPLFSF
     TFLLLVVPVN GHVDLKSNLT PPLITHTAAT PMPVPKLPVG GESNPGYESR RGSSSSVDPA
     CYDKSPTSVR SSSPYAPWSS GSGRTSRRSS WNSLGRAPSY KRQKRQSGER RSLLSGEGGS
     SSEDGEGGGE GGGGLMEEDD ASLARTDSML LRWLEKKQPA WCKQRDTWSL YLFPSESRFR
     ILCNKIITHK MFDHVVLVII FLNCITIAME RPRIDSKSAE RVFLTVSNYI FTSIFVAEMT
     VKIVSMGFFF GDKAYLRSSW NVLDGMLVMI SVIDILVSLI SQSETKILGM LRVLRLLRTL
     RPLRVISRAP GLKLVVETLM SSLKPIGNIV VICCAFFIIF GILGVQLFKG KFFICQGEDV
     RNITNKSDCL QANYKWVRHK YNFDNLGQAL MSLFVLASKD GWVDIMYDGL DAVGVDQQPI
     MNYNPWMLLY FISFLLIVAF FVLNMFVGVV VENFHKCRRH QEAEEAKRRE EKRLKRMEKK
     RRSKEKDLVV TCSGSVESAA DCGAQSKPYY SDYSPTRLLI HKMCTSHYLD LFITIVIGLN
     VITMSMEHYQ QPKELDEALK ICNYIFTLIF VLESVFKLVA FGFRRFFKDK WNQLDLAIVL
     LSIMGITLEE IEVNASLPIN PTIIRIMRVL RIARVLKLLK MAVGMRALLD TVMQALPQVG
     NLGLLFMLLF FIFAALGVEL FGDLICDELH PCEGLGRYAT FKNFGMAFLL LFRVSTGDNW
     NGIMKDTLRD CAQDTGTCYN TVVSPIYFVS FVLTAQFVLV NVVIAVLMKH LEESNKEAKE
     EAELEAEMME LEMEAGDMAA RSPQLNPLTL GMDRALFDSV SLVIQGSMEG EMSLMDNLSG
     SICHYYALPP KPSKHSTDKK IPLAEMDALS LASENSWSLA LTDDSTPDDF NPLFLTTLEC
     NVLTVPLFIL LHCYFFSFPS AVACTVSFTG YFQSHLTLPT TKLTHWGLTR GSQLDHCALC
     AGSSGSVRSQ PAEFSQQLTV PTDLFRPISP HSHSDSESIP RNPPSRRTHT FSRTLRRQVS
     KTHRFRFPLD SKFTFLVLSC LHCLASYSPC PSPPPPIPAR PPQQEVSEDR EVSLINQVVL
     AGSDDITAED SSSGGGNKGY GSYAGCQESR SPCLRQLKRF HSADTQGRNA LLPRPRPYSW
     LDDPRRHSVE VCSPIQSQIP AQTSPRMPPP LPNRDTYLRR RAPSSDSKDS FDLAVGEGSG
     QDGGSPNPNT NSKLLTLPMT SAPGLLAPTA VAI
//
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