ID I3KUH4_ORENI Unreviewed; 646 AA.
AC I3KUH4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Eomesodermin {ECO:0000313|Ensembl:ENSONIP00000024770.2};
GN Name=LOC100693371 {ECO:0000313|Ensembl:ENSONIP00000024770.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024770.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000024770.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_005457234.1; XM_005457177.3.
DR AlphaFoldDB; I3KUH4; -.
DR STRING; 8128.ENSONIP00000035766; -.
DR Ensembl; ENSONIT00000024791.2; ENSONIP00000024770.2; ENSONIG00000019678.2.
DR GeneID; 100693371; -.
DR CTD; 64603; -.
DR eggNOG; KOG3585; Eukaryota.
DR GeneTree; ENSGT00940000158728; -.
DR HOGENOM; CLU_014430_8_1_1; -.
DR OrthoDB; 5323209at2759; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000005207; Linkage group LG22.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032385; T-box_assoc.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF13; EOMESODERMIN HOMOLOG; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF16176; T-box_assoc; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 214..399
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 23..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 70942 MW; A7ECBCCBA211A206 CRC64;
MQLENILPSA NINLPKTFYN LSSSDSANNS PRPSSQLEYQ DVDRTESESS NAPKKYLSGV
GNGMLGEGEG DTFTKAGPDG RKGSPVLGED DLTNGRRYNI DELGSDRYFI SSSQASSDMA
SPCSLFPYAG QTGSVYTGSS SSRYPASLHY GSVLPPTGFS SSSVCTGRSQ FSSGGYQFSQ
GPGCLYPSYP GTGTGIGSMS LPGSAAGARA QVYLCNRPLW LKFHRHQTEM IITKQGRRMF
PFLSFNITGL NLTAHYNVFV EIVLADPNHW RFQGGKWVTC GKADNNMQGN KVYVHPESPN
TGAHWMRQEI SFSKLKLTNN KGANNNNTQM IVLQSLHKYQ PRLHIVEVTE DGVEDMSNEA
RTQTFTFPEN QFIAVTAYQN TDITQLKIDH NPFAKGFRDN YDSMYTAPES DRLTPSPTDS
PRSTQIVPGA RYAMQPFFQD QFVNNLPQNR FYPGERAVPQ TNSLLSPQSE DASAAASAQR
WFVPPVQQPG SNKLDLSYEN DYSTSSLLSY GIKPLSLQTS HALSYYPDSA FASMAAGWGT
RSSYQRKMTT GLPWSPRPSP PAFPEDQLGA TKEKLPEENA PPTSTWIETS HSLKSVDSAD
SGVYSMVCKR RRMSPGGSST ENSPTIKCED LTTEEYNKDN PKGAKA
//
