ID I3KUR8_ORENI Unreviewed; 393 AA.
AC I3KUR8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 4 {ECO:0000256|ARBA:ARBA00014934};
DE AltName: Full=26S proteasome regulatory subunit RPN10 {ECO:0000256|ARBA:ARBA00044341};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024864.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000024864.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the proteasome subunit S5A family.
CC {ECO:0000256|ARBA:ARBA00005574}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3KUR8; -.
DR STRING; 8128.ENSONIP00000024864; -.
DR Ensembl; ENSONIT00000024885.2; ENSONIP00000024864.2; ENSONIG00000019752.2.
DR eggNOG; KOG2884; Eukaryota.
DR GeneTree; ENSGT00530000064050; -.
DR HOGENOM; CLU_033293_0_1_1; -.
DR InParanoid; I3KUR8; -.
DR OMA; QMSMQDQ; -.
DR TreeFam; TF106232; -.
DR Proteomes; UP000005207; Linkage group LG22.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR CDD; cd22297; PSMD4_RAZUL; 1.
DR CDD; cd01452; VWA_26S_proteasome_subunit; 1.
DR Gene3D; 6.10.250.380; -; 1.
DR Gene3D; 6.10.300.40; -; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR049590; PSMD4_RAZUL-like.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10223; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR10223:SF13; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02809; UIM; 2.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00726; UIM; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50330; UIM; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 26..209
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 246..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 42518 MW; 660C733989D32DF6 CRC64;
LKVLWSGKNS TNVFLCVFIK PLAVSMEVYH VDNSEYMRNG DFLPTRLQAQ QDAVNIVCHS
KTRSNPENNV GLITMANNCE VLTTLTPDTG RILSKLHAVQ PRGKISFCTG IRVAHLALKH
RQGKNHKMRI IAFVGSPVED NEKDLVKLAK RLKKEKVNVD IINFGEEEVN TEKLTAFINT
LNGKEGTGSH LVTVPPGPSL ADALLSSPIL AGEGGSMMGL GASDFEFGVD PSADPELALA
LRVSMEEQRQ RQEEEARRAA AASAAEAGVP TPSADESEEA LLKMSVSQPE SGAAVLPDFS
SMTEEEQIAY AMQMSLAGGE YGEMDTGAPM DTAESAKEED DYDVMQDPEF LQSVLENLPG
VDPNNEAIRN AMGSLASQTG NKPDGKKDEE KKK
//
