GenomeNet

Database: UniProt
Entry: I3KVS1_ORENI
LinkDB: I3KVS1_ORENI
Original site: I3KVS1_ORENI 
ID   I3KVS1_ORENI            Unreviewed;       427 AA.
AC   I3KVS1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   08-NOV-2023, entry version 56.
DE   RecName: Full=SPRY domain-containing SOCS box protein 3 {ECO:0000256|ARBA:ARBA00014684};
GN   Name=LOC100698111 {ECO:0000313|Ensembl:ENSONIP00000025217.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025217.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000025217.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC       (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC       complex which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000256|ARBA:ARBA00004094}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the SPSB family.
CC       {ECO:0000256|ARBA:ARBA00010910}.
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DR   RefSeq; XP_019218262.1; XM_019362717.1.
DR   AlphaFoldDB; I3KVS1; -.
DR   STRING; 8128.ENSONIP00000025217; -.
DR   Ensembl; ENSONIT00000025238.2; ENSONIP00000025217.2; ENSONIG00000020023.2.
DR   GeneID; 100698111; -.
DR   CTD; 100005459; -.
DR   eggNOG; KOG3953; Eukaryota.
DR   GeneTree; ENSGT01030000234629; -.
DR   HOGENOM; CLU_042284_0_0_1; -.
DR   InParanoid; I3KVS1; -.
DR   OMA; ESCCSEP; -.
DR   OrthoDB; 4057255at2759; -.
DR   TreeFam; TF312822; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03587; SOCS; 1.
DR   CDD; cd12876; SPRY_SOCS3; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035754; SPRY_SPSB3.
DR   PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR   PANTHER; PTHR12245:SF5; SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          103..292
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   DOMAIN          292..327
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          342..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..357
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  47592 MW;  7C3598E342DD33FE CRC64;
     MSHCNTVSRK TTARTAMLRR GRNRRARHLA WNQTWQETDA MAVIQSSDRE EQEGQTVAQI
     SYLEPEVDYR AGFQTVSEVV ALPSTVPVKQ EYFFHCDPEE ELSPGLGVIS DCLYEEDDQG
     FDWVWDDHCK SSGAFLSCDN RKVSFHSDYS CGTAAIRGNK ELADGQHYWE IKMTSPVYGT
     DMMVGVGTSE VNLEKFKYNF GSLLGHDEDS WGLSYTGLFQ HKGDKIKFSS RFGQGSIIGV
     HLDTWHGTLT FYKNRHCIGV AATRLHNKKL YPMVCSTAAK SSMKVMRACY TPTSLQYLCC
     ARLRQMLPCC PDLFNALDLP PGLRVLLHIQ LGWVFSLSSS PEPSEEQEDF GKTSLPSSPS
     PNPSPSPVSS ACASPSPCTS PIPNTDPYPS PQTHSSACSC PPTPPSSDYE SCCSEPEDYQ
     CKRCRWT
//
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