ID I3KVS1_ORENI Unreviewed; 427 AA.
AC I3KVS1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 08-NOV-2023, entry version 56.
DE RecName: Full=SPRY domain-containing SOCS box protein 3 {ECO:0000256|ARBA:ARBA00014684};
GN Name=LOC100698111 {ECO:0000313|Ensembl:ENSONIP00000025217.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025217.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000025217.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC complex which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000256|ARBA:ARBA00004094}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the SPSB family.
CC {ECO:0000256|ARBA:ARBA00010910}.
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DR RefSeq; XP_019218262.1; XM_019362717.1.
DR AlphaFoldDB; I3KVS1; -.
DR STRING; 8128.ENSONIP00000025217; -.
DR Ensembl; ENSONIT00000025238.2; ENSONIP00000025217.2; ENSONIG00000020023.2.
DR GeneID; 100698111; -.
DR CTD; 100005459; -.
DR eggNOG; KOG3953; Eukaryota.
DR GeneTree; ENSGT01030000234629; -.
DR HOGENOM; CLU_042284_0_0_1; -.
DR InParanoid; I3KVS1; -.
DR OMA; ESCCSEP; -.
DR OrthoDB; 4057255at2759; -.
DR TreeFam; TF312822; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03587; SOCS; 1.
DR CDD; cd12876; SPRY_SOCS3; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035754; SPRY_SPSB3.
DR PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR PANTHER; PTHR12245:SF5; SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 103..292
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 292..327
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 342..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 47592 MW; 7C3598E342DD33FE CRC64;
MSHCNTVSRK TTARTAMLRR GRNRRARHLA WNQTWQETDA MAVIQSSDRE EQEGQTVAQI
SYLEPEVDYR AGFQTVSEVV ALPSTVPVKQ EYFFHCDPEE ELSPGLGVIS DCLYEEDDQG
FDWVWDDHCK SSGAFLSCDN RKVSFHSDYS CGTAAIRGNK ELADGQHYWE IKMTSPVYGT
DMMVGVGTSE VNLEKFKYNF GSLLGHDEDS WGLSYTGLFQ HKGDKIKFSS RFGQGSIIGV
HLDTWHGTLT FYKNRHCIGV AATRLHNKKL YPMVCSTAAK SSMKVMRACY TPTSLQYLCC
ARLRQMLPCC PDLFNALDLP PGLRVLLHIQ LGWVFSLSSS PEPSEEQEDF GKTSLPSSPS
PNPSPSPVSS ACASPSPCTS PIPNTDPYPS PQTHSSACSC PPTPPSSDYE SCCSEPEDYQ
CKRCRWT
//