ID I3KW64_ORENI Unreviewed; 1001 AA.
AC I3KW64;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Zinc finger FYVE-type containing 28 {ECO:0000313|Ensembl:ENSONIP00000025360.2};
GN Name=zfyve28 {ECO:0000313|Ensembl:ENSONIP00000025360.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025360.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025360.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the lst-2 family.
CC {ECO:0000256|ARBA:ARBA00008755}.
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DR RefSeq; XP_003453144.1; XM_003453096.4.
DR AlphaFoldDB; I3KW64; -.
DR Ensembl; ENSONIT00000025381.2; ENSONIP00000025360.2; ENSONIG00000020131.2.
DR GeneID; 100697092; -.
DR KEGG; onl:100697092; -.
DR CTD; 57732; -.
DR eggNOG; KOG1819; Eukaryota.
DR GeneTree; ENSGT00940000157217; -.
DR InParanoid; I3KW64; -.
DR OMA; PELGYDR; -.
DR OrthoDB; 5394048at2759; -.
DR TreeFam; TF320752; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46465; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR46465:SF2; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 931..987
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 308..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 110846 MW; 7720406689732DA5 CRC64;
MNRFRKWLYK PKRTDPQLLA QFYYADEELN QVATELDSLD GRKDPQRCTL LVNQFRSCQD
NVLNIISQIM DECIPFDRAN RDFCVKFPEE IRHDNLAGQL WFGAECLAAG SIIMNREIES
IAMRPLAKDL TRSLEEVRNI TRDQALRDLN LYTDRMKDAL RHFDSLFAEF ELSYVSAMVP
VKSPKEYYVQ QEVIVLFCET VERALKLGYL TQDMIDDYEP ALMFTIPRLA IVCGLVVYPE
GPLNLDRKSE DMSELFRPFR TLLKKIRDLL QTLTEEELMT LERNLCISQE GELSTSQGLA
TNGVPAPVQE NHSSCSPANE ISKRGSEGEE APLAVLVCPS QEEELAGVEK GWEEVETVRG
EEEQEQGLLC EEAEEAELAC SMQYDEEELE QLNMMVYRVG DEMSTLLSPP SQGQSPAHDP
NRGQPAGSSG ASSTEVSPRR ILGSRGRTGI CTEEEDRVFF MEDLDAAGEH ITREPRCYVT
SPPKESARPV QRKPAPRPDS VRNGWFSETT SEQPCPQPRN LNTHCPTAKC PPCTNVPGSE
ALPYTNGWDM GLEGTASETA EVIAHRMGGM KLSATVIFNP HSPSLTELAV DKLLLPRPTP
SEIEPCGPLV ATHCLLNSCV CCGSCEDGHE DAITTETTGL GLGLALGLDK HCTTPASSAV
IQSSACRLPP RPHEHNNKDD VAHLSTPSSR SAEPLEEAPG LGHQTQDCSS SVKNGASPCN
HQLRTEKRHA SGGRQRDKEI DNENTENKDM KRYTKEDTRR SSSFQNSPLS SVSGSDCESV
SVTTCSLSSS AYTPSPVSSL TPSSGTSEDP DQQEIQLAVQ DAKAAARSKI RSRFHSSSDL
IHRLFVCISG VADQLQTNYA SDLRSILKTL FEVMATKCEE GDNDKQKKAG PVMRSAVLED
CALCQETISS SELAAKAREG QFEDPPDWVP DEACNSCIAC KAPFTVIRRK HHCRSCGKIF
CSRCSSHSAP LPRYGQVKPV RVCTHCYMFH VTPFYSDKAG I
//
