ID I3KWN3_ORENI Unreviewed; 1049 AA.
AC I3KWN3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Contactin-3 {ECO:0000313|Ensembl:ENSONIP00000025529.2};
GN Name=LOC100696343 {ECO:0000313|Ensembl:ENSONIP00000025529.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025529.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025529.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with PTPRG. {ECO:0000256|ARBA:ARBA00038703}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin
CC family. {ECO:0000256|ARBA:ARBA00009812}.
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DR AlphaFoldDB; I3KWN3; -.
DR STRING; 8128.ENSONIP00000047474; -.
DR Ensembl; ENSONIT00000025550.2; ENSONIP00000025529.2; ENSONIG00000020260.2.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000155198; -.
DR HOGENOM; CLU_005756_0_0_1; -.
DR TreeFam; TF351103; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF18; CONTACTIN 4-RELATED; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 5.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1049
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025387494"
FT DOMAIN 28..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 124..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 230..316
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 321..403
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 409..498
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 500..588
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 601..699
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 704..800
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 805..899
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 904..996
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 686..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 114345 MW; CB1F88DB79FD0040 CRC64;
MLPWKQIVLL SITGCLAACT EDVIFQGPRW RTEPSDLILP INSPDHQATI TCEAEGSPPP
QYRWSLNGTL IDLGNDYRRH MSGGSLIISN LDKDQDTGVY QCTAFNMWGS ILSRRASLQF
AYLDNFKTQS VRSAVNVREG QGVVLLCGPP PHSGELTFAW IFNEYPHFVQ QDSRRFISQE
TGSLYIAKVE RSDVGNYTCV VNNTVTREKI LSSPTPLVLR SDGVMGEYEP KIEVHFPDSV
PAAKESAVKL ECFALGNPVP EISWRRTSGV PFPSKVKMKN SNAVLEIPNF QQEDAGTYEC
MAENRRGKNA ARGRISFHAK PHWLQTMADT ALSIEGNLFW ECKANGKPKP SYSWLKNGEQ
VMGRVQIENG ALSISSLNRS DSGMYQCVAE NKHGIIYSSA QLMVLASPPT FSKSPLRALL
KARSGSEVTL ECKPQASPPA ISLWKKGNEI LQRTERIALL PDGTLKIANV TKRDAASYTC
IAKNQFGTAS TTGRLIVTEP TRITMRPTNM EIIVGESIVL PCQIASDPAL DVSFSWAFNG
QLIDFQRDSD HFERVGGSIS GDLMIRNIQL NHGGKYVCVI DTDVESLSTS AILVVKGPPG
PPDKVSVEEI TDSTAQLSWT PGRDNGSPIT GYIVQARTPF TVGWQAVDTV PEVVNGNMLT
ATVVGLNAWV EYEFRVVARN AVGLGEPSPA SAKTRTEDAI PDTAPTDVGG GGGTKSELVI
TWEPVPEELQ NGEGFGYIIA FRPVGTVTWT RAVISTSAAR YVFRNDTIPP FSPFDVKVGA
YNNRGEGPFS SIAVVYSAEE VPSVAPKRVR ARSVSAAQIE VSWEALPTIP ERVLGYEVMY
WEDDTKPDTI GKVRLSGNYT LVNITGLKAN TAYYLSVAAF NTAGPGPQSA PINSTTKKPP
PDRAPLNIQW NMIGSTLTLH WNPVVAMETE SKVTGYLVSP TILHRYNDIL TVLTNRTTAE
LSLSANDNYL IQIKAVSEGG EGVGSEPIHI HKLSDDLFRN ACTVSSISAI GLLFLVDWLL
SAAAYKAVLC SHPAAVQNCE AARFGALLF
//
