ID I3KWR4_ORENI Unreviewed; 909 AA.
AC I3KWR4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Glutamate receptor, metabotropic 6b {ECO:0000313|Ensembl:ENSONIP00000025560.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025560.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025560.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; I3KWR4; -.
DR STRING; 8128.ENSONIP00000054820; -.
DR Ensembl; ENSONIT00000025581.2; ENSONIP00000025560.2; ENSONIG00000020285.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234648; -.
DR HOGENOM; CLU_005389_0_0_1; -.
DR TreeFam; TF313240; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15286; 7tmC_mGluR_group3; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF170; GLUTAMATE RECEPTOR, METABOTROPIC 6B; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..49
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 50..909
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025411500"
FT TRANSMEM 603..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 673..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 767..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 603..877
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 909 AA; 101645 MW; 1A75505A10C5E2D3 CRC64;
MFCSAKFIVF SIIVLSSHQC SWFGTSYGYK PWLRLLWVLL VGFSPASRAQ QGTQPQSIKI
EGDITLGGLF PVHSRGPAGV PCGEIKREKG IHRLEAMLYA LDQINSDPEL LPNITLGARI
LDTCSRDTYA LEQSLTFVQA LIQKDNSDVR CSNGEPPIIP KPERVVGVIG ASGSSVSIMV
ANVLRLFAIP QISYASTAPE LSDNSRYEFF SRVVPPDSYQ AQAMVDIVKN MGWNYVSTLA
SEGNYGESGV DAFLQISREA GGLCIAQSIK IPREPRPGEF DKIIKRLMET SNARGVIIFA
NEDDIKRVLQ AAKKANLTGH FLFVGSDSWG SKNSAIEDQE EVAEGAVTIL PKRASIDGFD
QYFTSRSLEN NRRNIWFAEF WEDDFKCKLT RPGIKYDPGR RKCTGEERIS RDSQYEQEGK
VQFVIDAVYA MAHALHSMHL DLCAGSMGVC EKMDPVDGRM LLQYIRSVNF NGSAGTGVMF
NENGDAPGRY DIFQYQMSNV SNPGYKNIGQ WTNHLRLNVN EMQWSGGDRK IPESVCSFPC
ESGERKKMVK GVPCCWHCEL CDGYQYLLDE FTCDMCPFDM RPLENRTGCR PTPIIKLEWS
SPWAIIPVFL AILGILATTG VIVTFIRFND TPIVRASGRE LSYVLLTGIF LIYLITFFMI
AEPSVAICAF RRLFLGLGMC ISYAAMLTKT NRIYRIFEQG KKSVTPPKFI SPTSQLIITF
ILISVQLLAV FIWFGVMPPH TIIDYEEQKP PNPEFARGIL KCDMSDLSLI LCLSYSIVLM
ITCTVYAIKS RGVPETFNEA KPIGFTMYTT CIIWLAFVPI FFGTAQSTEK MFIQTTTLTV
SMSLSATVSL GMLYVPKVYV IIFHPEQNVQ KRKRSFKAVV QAATVTTHLS LKSNDKQNGE
SKVEPDRSQ
//
