ID I3KWR5_ORENI Unreviewed; 873 AA.
AC I3KWR5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Glutamate receptor, metabotropic 6b {ECO:0000313|Ensembl:ENSONIP00000025561.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025561.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025561.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; I3KWR5; -.
DR Ensembl; ENSONIT00000025582.2; ENSONIP00000025561.2; ENSONIG00000020285.2.
DR GeneTree; ENSGT01030000234648; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15286; 7tmC_mGluR_group3; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF170; GLUTAMATE RECEPTOR, METABOTROPIC 6B; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 578..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 817..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 578..852
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 873 AA; 97540 MW; 7615F6C0010CA238 CRC64;
MRFKSDALFK YSTQTASWTP ASRAQQGTQP QSIKIEGDIT LGGLFPVHSR GPAGVPCGEI
KREKGIHRLE AMLYALDQIN SDPELLPNIT LGARILDTCS RDTYALEQSL TFVQALIQKD
NSDVRCSNGE PPIIPKPERV VGVIGASGSS VSIMVANVLR LFAIPQISYA STAPELSDNS
RYEFFSRVVP PDSYQAQAMV DIVKNMGWNY VSTLASEGNY GESGVDAFLQ ISREAGGLCI
AQSIKIPREP RPGEFDKIIK RLMETSNARG VIIFANEDDI KRVLQAAKKA NLTGHFLFVG
SDSWGSKNSA IEDQEEVAEG AVTILPKRAS IDGFDQYFTS RSLENNRRNI WFAEFWEDDF
KCKLTRPGIK YDPGRRKCTG EERISRDSQY EQEGKVQFVI DAVYAMAHAL HSMHLDLCAG
SMGVCEKMDP VDGRMLLQYI RSVNFNGSAG TGVMFNENGD APGRYDIFQY QMSNVSNPGY
KNIGQWTNHL RLNPEEMQWS GGDRKIPESV CSFPCESGER KKMVKGVPCC WHCELCDGYQ
YLLDEFTCDM CPFDMRPLEN RTGCRPTPII KLEWSSPWAI IPVFLAILGI LATTGVIVTF
IRFNDTPIVR ASGRELSYVL LTGIFLIYLI TFFMIAEPSV AICAFRRLFL GLGMCISYAA
MLTKTNRIYR IFEQGKKSVT PPKFISPTSQ LIITFILISV QLLAVFIWFG VMPPHTIIDY
EEQKPPNPEF ARGILKCDMS DLSLILCLSY SIVLMITCTV YAIKSRGVPE TFNEAKPIGF
TMYTTCIIWL AFVPIFFGTA QSTEKMFIQT TTLTVSMSLS ATVSLGMLYV PKVYVIIFHP
EQNVQKRKRS FKAVVQAATV TTHLSLNESA KET
//
