ID I3KXB0_ORENI Unreviewed; 628 AA.
AC I3KXB0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Leucine-rich repeat-containing protein 4C {ECO:0000313|Ensembl:ENSONIP00000025756.1};
GN Name=LRRC4C {ECO:0000313|Ensembl:ENSONIP00000025756.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025756.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025756.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
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DR RefSeq; XP_003450848.1; XM_003450800.4.
DR AlphaFoldDB; I3KXB0; -.
DR STRING; 8128.ENSONIP00000025756; -.
DR Ensembl; ENSONIT00000025777.2; ENSONIP00000025756.1; ENSONIG00000020451.2.
DR GeneID; 100704093; -.
DR KEGG; onl:100704093; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157405; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; I3KXB0; -.
DR OMA; NNGVTYF; -.
DR OrthoDB; 4239630at2759; -.
DR TreeFam; TF324303; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0097060; C:synaptic membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF8; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..45
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 46..628
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003675302"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 355..442
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 465..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 70226 MW; 6C76AFEAA386E518 CRC64;
MLNTMISSLQ RQTMRGRRLK GALSNPLFVL LLALQILVVA GLVRAQTCPS VCSCSNQFSK
VICTRRSLRD VPDGISTNTR YLNLQDNLIQ VIKVDSFKHL RHLEILQLSK NHIRSIEIGA
FNGLASLNTL ELFDNRLTTI PNGAFEYLSK LKELWLRNNP IESIPSYAFN RVPSLRRLDL
GELKRLSYIS DGAFKDLSNL RYLNLGMCNL KEIPNILPLV RLEELEMSGN QLSVIKPSSF
TGLVNLQKLW MMHAQIQTIE RNSFDDLQSL VELNLAHNNL TFLPHDLFTP LHRLERVHLH
HNPWNCNCDI LWLSWWLKET VPANTSCCAR CHTPSTLKGR YIGELDHSYF QCDVPVIVEP
PSDLNVTEGM GAELKCRTSS VTSISWLTPN GSLVTHGAYK VRLSVLNDGT LNFTSVTMQD
TGTYTCMVSN TAGNISASAV LNVTSLDSSG VTYFTTVTVE TTDMMGEDSQ TPLPPFGWVS
SSTTKGTPVS TRTTERTYTI PVLDPEGEGS LDEVMKTTKI IIGCFVAITL MAAVLLVIFY
KMRKQHNQQD PDGPASSMEV ITVEEELAGV AAMERHLSLP PLEHYNHYNT YKSSYHHPPM
LSTIHSSATQ EPLLIQACSK DNVQETQI
//
