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Database: UniProt
Entry: I3KXS0_ORENI
LinkDB: I3KXS0_ORENI
Original site: I3KXS0_ORENI 
ID   I3KXS0_ORENI            Unreviewed;       413 AA.
AC   I3KXS0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-OCT-2019, entry version 39.
DE   SubName: Full=NHL repeat containing E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSONIP00000025916};
GN   Name=NHLRC1 {ECO:0000313|Ensembl:ENSONIP00000025916};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025916, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000025916}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
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DR   EMBL; AERX01033828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000025916; -.
DR   Ensembl; ENSONIT00000025937; ENSONIP00000025916; ENSONIG00000020611.
DR   eggNOG; ENOG410ITF2; Eukaryota.
DR   eggNOG; ENOG410ZMHC; LUCA.
DR   GeneTree; ENSGT00730000111361; -.
DR   InParanoid; I3KXS0; -.
DR   OMA; WGTLINP; -.
DR   TreeFam; TF331018; -.
DR   Proteomes; UP000005207; Unplaced.
DR   Gene3D; 2.120.10.30; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF01436; NHL; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 6.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN       30     77       RING-type. {ECO:0000259|PROSITE:PS50089}.
FT   REPEAT      134    170       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      174    217       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      228    258       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      273    316       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      339    365       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      378    408       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
SQ   SEQUENCE   413 AA;  44741 MW;  50EF63B252CC1FBD CRC64;
     ISVMAKSLQH RGCLSPEGII REIQINLLEC KVCFETFSSQ QRERRPQNLS CGHVLCLECI
     TALSHPLLRK LECPFCRQLC SVDSTSHCQV LSDLKDLLLS QSPSPSAPSC RAKAGFIFPT
     ALTCTTLLLR TAFGGWGTLI NPTGIAVLGS SGTIVVVHDG EKRVVVFNLQ GKKLHSFGQK
     GAASGEICYP VDVAVTPAGH VVVTDAGDKA VKVFTSRGNH VLTIKDSFQM PWGVDTDSCG
     HILVSDVEAG TLSKVRVDYS NGVILEHQTT ISDLQCPKAV AYCCVNGNTA VTEHLTDVTN
     PTERHQHRRI RVFTKEFHLL YQTDTFSLTL QSTVRLSFSG VAFDRDGDLI VIDSDQGMIW
     SLGKLQSGPV LTPLVGDHLV RPVGLALLNN LLITLDSGDH TVKIYSPKSD AGP
//
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