ID   I3KY86_ORENI            Unreviewed;       907 AA.
AC   I3KY86;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000026083.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000026083.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KY86; -.
DR   STRING; 8128.ENSONIP00000026083; -.
DR   Ensembl; ENSONIT00000026104.2; ENSONIP00000026083.2; ENSONIG00000031728.1.
DR   eggNOG; KOG1075; Eukaryota.
DR   GeneTree; ENSGT00940000164735; -.
DR   HOGENOM; CLU_000680_9_4_1; -.
DR   InParanoid; I3KY86; -.
DR   TreeFam; TF351901; -.
DR   Proteomes; UP000005207; Linkage group LG6.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR31635:SF196; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31635; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          141..413
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   907 AA;  107265 MW;  72CFC7B891CB00D3 CRC64;
     MFLKQRHYES GSKSMKILAW KLKKKIAENT IHKIRDPRTK VIKNKLNEIQ EAFEIFYTTL
     YSEVPGGTVT QIDSFLNSLD LPTLDEEQNQ TMTADITEEE LKAAISRLKL SKSPGSDGYT
     AEWYKEFKKE LIPVLLPTLN WALKKAQTPP SWKEAIISAI PKEGKDKMEC GSYRPISVLN
     VDYKLYTSIM AKRLEEFLPT LIHNDQTGFI HQRQTQDNIR KTLHIMDHIQ KNKIKAIVIS
     VDAEKAFDSV NWNFLYRVLY KFGFHDTTIK TIQALYDNPT ARIKINGYLS NSFTLERGTR
     QGCAWSPLLF ALYLEPLAQF IRQNEDIKGI IIKGTEYKLA CYADDILVYL GHPTYSLPKL
     MHSFEQYGQL SGYKINIGKT QLLSYNYSPS DEMRSSYPLA WQTESFKYLG INLSKDLTKL
     FEQNYLPIYK KIKDDIARWN LIPFFNLSSR IDSIKMNIMP RFLYLFQTLP IEINQNQFNE
     WDKMLSRYIW QGKRPRVRLK TLQLAKQKGG WGLPYLRYYY FAVQMRAVIC WCNPSYTAQW
     KNLEEKMLPI PIQAILADNN LQTYINNMDN PWVKRTLKTW KTVIKEHKLE ANIIALKWCA
     YDSEFMPNKL DSRFKDWIAK GITDLCSIMK DGKLLSFETL KRTYLLEKQD FYRYLQLRHY
     VDTKMKNATK TGTRLIDLFI KSYNSETIDR IVSCLYKGLL DLISHSTSYI KIKWEKEGGI
     SISEEEWTAI WRYQWMCTSS QKWREFGWKS LIRYFITPSQ KCHYDNNSPV CWRNCGNQSA
     NHYHIFWDCS VLRDYWREIH NALQYIFKCE IPFESKTMFF GHVPQEWPKS DKHLVNILLM
     ACKKGITRKW LSPESPTINI WMDITMDIYK MEKITAFVNH KLDKFTSYWE NWVKYVTPHR
     PDFIFTN
//