ID I3KZD0_ORENI Unreviewed; 478 AA.
AC I3KZD0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ammonium transporter Rh type B {ECO:0000313|Ensembl:ENSONIP00000026477.2};
GN Name=LOC100692870 {ECO:0000313|Ensembl:ENSONIP00000026477.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000026477.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000026477.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an ammonia transporter. May play a role in the
CC elimination of ammonia in the gill. {ECO:0000256|ARBA:ARBA00025220}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000256|ARBA:ARBA00011036}.
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DR RefSeq; XP_003441408.1; XM_003441360.4.
DR AlphaFoldDB; I3KZD0; -.
DR STRING; 8128.ENSONIP00000026477; -.
DR Ensembl; ENSONIT00000026501.2; ENSONIP00000026477.2; ENSONIG00000021175.2.
DR GeneID; 100692870; -.
DR KEGG; onl:100692870; -.
DR CTD; 791729; -.
DR eggNOG; KOG3796; Eukaryota.
DR GeneTree; ENSGT00950000182844; -.
DR HOGENOM; CLU_021386_0_0_1; -.
DR InParanoid; I3KZD0; -.
DR OMA; GPSMYQI; -.
DR OrthoDB; 5483564at2759; -.
DR TreeFam; TF314450; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF48; RH50-LIKE PROTEIN; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 3: Inferred from homology;
KW Ammonia transport {ECO:0000256|ARBA:ARBA00023177};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..431
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
SQ SEQUENCE 478 AA; 52556 MW; CDBC25B6500AD175 CRC64;
MKDSVSLKVS LPVFVLVFEV IIIALYAVFV TYDDDTNAKL QNNETSPMEN SLYRDYPYFA
DVQVMIFIGF GCLLAFFRFY GFGGMVFNFL TATFAIQWAI LMQGFFQFYY DGKIHLGVIN
LVNAEFACAV VLISFGAVLG KTSPVQLLVM ASLEIPIFAV TEWAVLKYIR INDAGGTILI
HIFACYFGLG VTFMLYRPSL NDGHAKEITS YHSDILSVMG TLFLWVFWPS FNSALTFKGD
DQHRAILHTF IGLSSSTITA FALSALFNKR GKLTMADIQN VTLAGGVTVG ASVDMMISPV
AAYVLGVMGC TACFFGYKYL TPFMAYRMRI QDQCGIHNLH GLTGIISAAA GICAILLATE
ETYGPSMYQI FSHRAPPEGD PRLLELQKLI PGLKPGLGRT AQEQALYQVA AVFTTIGAST
VGGLLTGLVM KFPSLASPSD KKCFDDELFF ELPSDFSSVE VPLTYEEKGQ MNPMDTKV
//
