ID I3KZL1_ORENI Unreviewed; 307 AA.
AC I3KZL1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Transcription factor Jun {ECO:0000256|ARBA:ARBA00029507};
DE AltName: Full=Proto-oncogene c-Jun {ECO:0000256|ARBA:ARBA00031819};
DE AltName: Full=Transcription factor AP-1 subunit Jun {ECO:0000256|ARBA:ARBA00032537};
GN Name=JUN {ECO:0000313|Ensembl:ENSONIP00000026558.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000026558.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000026558.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the bZIP family. Jun subfamily.
CC {ECO:0000256|ARBA:ARBA00006882}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3KZL1; -.
DR STRING; 8128.ENSONIP00000026558; -.
DR Ensembl; ENSONIT00000026582.2; ENSONIP00000026558.2; ENSONIG00000021256.2.
DR eggNOG; KOG0837; Eukaryota.
DR GeneTree; ENSGT00940000162061; -.
DR HOGENOM; CLU_057007_0_0_1; -.
DR InParanoid; I3KZL1; -.
DR OMA; FVCPKNI; -.
DR TreeFam; TF323952; -.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd14696; bZIP_Jun; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR005643; JNK.
DR InterPro; IPR002112; Leuzip_Jun.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR11462; JUN TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR11462:SF8; TRANSCRIPTION FACTOR JUN; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF03957; Jun; 1.
DR PRINTS; PR00043; LEUZIPPRJUN.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 228..291
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 108..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..280
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 108..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..177
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33799 MW; DAE6E522BE1909C9 CRC64;
MSRKMEATFY DEASNSQHDG AAVYGFNPKT LKQTMTLNLN DPKNFKPHLG AKALDILTSP
DVGLLKLTTP TPTQFICPKN ITDEQEGFAE GFVRALAELH YQQQIPAAQP DPQTGSANGM
TSGSAAPESG GISYSCTVRT EPPEYTNLSS FTRAVTGSTP APAGERQPPP PTSYPAAPQP
SHNHMDHQLP VAAQHPRLHA LKEEPQTVPE MSGETPPLSP IDMESQERIK AERKRMRNRV
AASKCRKRKL ERIARLEERV KNLKSQNTEL VSSANVLRDE LALLKQKVMD HVNSGCQLIL
TQQLQAY
//
