ID   I3L016_ORENI            Unreviewed;       236 AA.
AC   I3L016;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=Gremlin-1 {ECO:0000256|ARBA:ARBA00040888};
GN   Name=GREM1 {ECO:0000313|Ensembl:ENSONIP00000026713.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000026713.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000026713.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
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DR   AlphaFoldDB; I3L016; -.
DR   STRING; 8128.ENSONIP00000026713; -.
DR   Ensembl; ENSONIT00000026737.2; ENSONIP00000026713.2; ENSONIG00000021411.2.
DR   eggNOG; ENOG502RXHZ; Eukaryota.
DR   GeneTree; ENSGT00940000154209; -.
DR   HOGENOM; CLU_101024_0_0_1; -.
DR   InParanoid; I3L016; -.
DR   OMA; SCEAFIN; -.
DR   TreeFam; TF106445; -.
DR   Proteomes; UP000005207; Linkage group LG15.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   PANTHER; PTHR15283; GREMLIN 1; 1.
DR   PANTHER; PTHR15283:SF3; GREMLIN-1; 1.
DR   Pfam; PF03045; DAN; 1.
DR   SMART; SM00041; CT; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          148..235
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|SMART:SM00041"
SQ   SEQUENCE   236 AA;  26392 MW;  CD3AE0FF4B780D67 CRC64;
     MGLGACSGET QNWISPHCVI HKTTTEDGGP LEDTHADWII VFSLGVLKKT NQKTGSTMER
     HSVQSFAVIL ALLLTPLKST KAQSFQSAFP QPNKHSPNES ATCVQPPLIG LISRATGPVT
     STYEVPESSQ EALHVTERRY LRLDWCKTQP LKQTIEEEGC LRRTIINRFC YGQCNSFYIP
     RNKYQDGNAF RSCSACKPKS FSTVTYTLLC PGQTPSTKRK RVQRVKLCRC TTIDMD
//