ID I3L120_HUMAN Unreviewed; 260 AA.
AC I3L120;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Tubulin folding cofactor D {ECO:0000313|Ensembl:ENSP00000458512.1};
DE Flags: Fragment;
GN Name=TBCD {ECO:0000313|Ensembl:ENSP00000458512.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458512.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000458512.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000458512.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC024361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC068014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC068584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC087222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC130371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3L120; -.
DR MassIVE; I3L120; -.
DR MaxQB; I3L120; -.
DR PeptideAtlas; I3L120; -.
DR ProteomicsDB; 46508; -.
DR Antibodypedia; 33047; 89 antibodies from 21 providers.
DR Ensembl; ENST00000577051.1; ENSP00000458512.1; ENSG00000141556.22.
DR UCSC; uc060mfb.1; human.
DR HGNC; HGNC:11581; TBCD.
DR VEuPathDB; HostDB:ENSG00000141556; -.
DR GeneTree; ENSGT00390000017103; -.
DR HOGENOM; CLU_059779_0_0_1; -.
DR ChiTaRS; TBCD; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000141556; Expressed in right lobe of thyroid gland and 93 other cell types or tissues.
DR ExpressionAtlas; I3L120; baseline and differential.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0007021; P:tubulin complex assembly; IEA:InterPro.
DR InterPro; IPR033162; TBCD.
DR InterPro; IPR022577; Tubulin_specific_chaperoneD_C.
DR PANTHER; PTHR12658; BETA-TUBULIN COFACTOR D; 1.
DR PANTHER; PTHR12658:SF0; TUBULIN-SPECIFIC CHAPERONE D; 1.
DR Pfam; PF12612; TFCD_C; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:I3L120,
KW ECO:0007829|MaxQB:I3L120};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..131
FT /note="Tubulin-specific chaperone D C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12612"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000458512.1"
SQ SEQUENCE 260 AA; 28911 MW; 58C94FF00CD5180C CRC64;
AQQASEKIDR FRAHAASVFL TLLHFDSPPI PHVPHRGELE KLFPRSDVAS VNWSAPSQAF
PRITQLLGLP TYRYHVLLGL VVSLGGLTES TIRHSTQSLF EYMKGIQSDP QALGSFSGTL
LQIFEDNLLN ESHPFAVKLL ALCKKEIKNS KDIQKLLSGI AVFCEMVQFP GDVRRQALLQ
LCLLLCHRFP LIRKTTASQV YETLLTYSDV VGADVLDEVV TVLSDTAWDA ELAVVREQRN
RLCDLLGVPR PQLVPQPGAC
//
