ID I3L556_PIG Unreviewed; 457 AA.
AC I3L556;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=T-cell surface glycoprotein CD4 {ECO:0000256|ARBA:ARBA00016522};
DE AltName: Full=T-cell surface antigen T4/Leu-3 {ECO:0000256|ARBA:ARBA00029974};
GN Name=CD4 {ECO:0000313|Ensembl:ENSSSCP00000019155.3,
GN ECO:0000313|VGNC:VGNC:86417};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000019155.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000019155.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000019155.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000019155.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; NP_001001908.2; NM_001001908.2.
DR RefSeq; XP_005652647.1; XM_005652590.2.
DR AlphaFoldDB; I3L556; -.
DR STRING; 9823.ENSSSCP00000019155; -.
DR PaxDb; 9823-ENSSSCP00000000732; -.
DR Ensembl; ENSSSCT00000030772.4; ENSSSCP00000019155.3; ENSSSCG00000000687.5.
DR GeneID; 404704; -.
DR KEGG; ssc:404704; -.
DR CTD; 920; -.
DR VGNC; VGNC:86417; CD4.
DR GeneTree; ENSGT00390000001745; -.
DR HOGENOM; CLU_047414_0_0_1; -.
DR InParanoid; I3L556; -.
DR OMA; KTCQCSH; -.
DR TreeFam; TF335974; -.
DR Reactome; R-SSC-202424; Downstream TCR signaling.
DR Reactome; R-SSC-202427; Phosphorylation of CD3 and TCR zeta chains.
DR Reactome; R-SSC-202430; Translocation of ZAP-70 to Immunological synapse.
DR Reactome; R-SSC-202433; Generation of second messenger molecules.
DR Reactome; R-SSC-389948; PD-1 signaling.
DR Reactome; R-SSC-449836; Other interleukin signaling.
DR Reactome; R-SSC-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-SSC-8856828; Clathrin-mediated endocytosis.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000000687; Expressed in mesenteric lymph node and 32 other cell types or tissues.
DR ExpressionAtlas; I3L556; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IBA:GO_Central.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0042011; F:interleukin-16 binding; IEA:Ensembl.
DR GO; GO:0042012; F:interleukin-16 receptor activity; IEA:Ensembl.
DR GO; GO:0042289; F:MHC class II protein binding; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
DR GO; GO:0035723; P:interleukin-15-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:0032507; P:maintenance of protein location in cell; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0045657; P:positive regulation of monocyte differentiation; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
DR GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR GO; GO:0050863; P:regulation of T cell activation; IEA:Ensembl.
DR GO; GO:0042110; P:T cell activation; IBA:GO_Central.
DR GO; GO:0045058; P:T cell selection; IEA:Ensembl.
DR CDD; cd22570; CD4_CD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 1.20.5.900; transmembrane domain of human cd4; 1.
DR InterPro; IPR000973; CD4.
DR InterPro; IPR015274; CD4-extracel.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008424; Ig_C2-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR021963; Tcell_CD4_Cterm.
DR PANTHER; PTHR11422; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR PANTHER; PTHR11422:SF0; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR Pfam; PF05790; C2-set; 2.
DR Pfam; PF09191; CD4-extracel; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF12104; Tcell_CD4_C; 1.
DR PRINTS; PR00692; CD4TCANTIGEN.
DR SMART; SM00409; IG; 3.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..457
FT /note="T-cell surface glycoprotein CD4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036499101"
FT TRANSMEM 397..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..122
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 138..196
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 457 AA; 51043 MW; ED12CA00D90AFE25 CRC64;
MDPGTSLRHL FLVLQLAMLP AASGTQEKYL VLGKAGDLAE LPCHSSQKKN LPFNWKSSNQ
TKILGGHGSF WHTASVTELT SRLDSKKNMW DHGSFPLIIK NLEVTDSGIY ICEVEDKRIE
VQLLVFRLTA SVTRVLLGQS LTLTLEGPSG SHPTVQWKGP GNKSKNDVKS LLLPQVGLED
SGLWTCTVSQ DQKTLVFRSN IFVLAFQKVP STVYVKEGDQ VVLSFPLTFE AESLSGELMW
RQTKGASSPQ SWITFSLKDR KVTVQKSLQN LKLRMAEKLP LQITLLQALP QYAGSGNLTL
VLPEGRLHRE VNLVVMRATQ SKNEVTCEVL GPTPPKVVLS LKLGNQSMKV SDQQKLVTVL
DPEAGMWRCL LRDKDKVLLE SQVEVLPTAF TRAWPKLLAF VIGGIIGLLF LAGFCIVCVK
CWHRRRRAER MSQIKRLLSE KKTCQCAHRQ QKNYSLT
//
