ID I3L5S2_PIG Unreviewed; 392 AA.
AC I3L5S2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=CWC25 spliceosome associated protein homolog {ECO:0000313|Ensembl:ENSSSCP00000019372.2};
GN Name=CWC25 {ECO:0000313|Ensembl:ENSSSCP00000019372.2,
GN ECO:0000313|VGNC:VGNC:87096};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000019372.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000019372.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000019372.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000019372.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CWC25 family.
CC {ECO:0000256|ARBA:ARBA00006695}.
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DR AlphaFoldDB; I3L5S2; -.
DR Ensembl; ENSSSCT00000027397.4; ENSSSCP00000019372.2; ENSSSCG00000021478.4.
DR VGNC; VGNC:87096; CWC25.
DR GeneTree; ENSGT00440000039055; -.
DR HOGENOM; CLU_025093_1_0_1; -.
DR TreeFam; TF320801; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000021478; Expressed in blood and 46 other cell types or tissues.
DR ExpressionAtlas; I3L5S2; baseline and differential.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR019339; CIR_N_dom.
DR InterPro; IPR022209; CWC25.
DR PANTHER; PTHR16196; CELL CYCLE CONTROL PROTEIN CWF25; 1.
DR PANTHER; PTHR16196:SF0; PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG; 1.
DR Pfam; PF10197; Cir_N; 1.
DR Pfam; PF12542; CWC25; 1.
DR SMART; SM01083; Cir_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 11..47
FT /note="CBF1-interacting co-repressor CIR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01083"
FT REGION 164..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 23..66
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 175..194
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 45542 MW; 963839EA51AB3976 CRC64;
MGGGDLNLKK SWHPQTLRNV EKVWKAEQKH EAERKKIEEL QRELREERAR EEMQRYAEDV
GAVKKKEEKL DWMYQGPGGM VNRDEYLLGR PIDKYVFEKM EEKEAGCSSE TGLLPGSIFA
PSGANSLLDM ASKIREDPLF IIRKKEEEKK REVLNNPVKM KKIKELLQMS LVKKEKKKKK
EKKKKHKKHK HRGSSSDRCS SEDERGRGRS QKKLANSSPV LAKVPGYGLQ LRNSDRSQGP
RGPPVAEQRA GHGLKNYSRS RSSSPSPPRH ASKKSTREAG SRDRRSRSPG RRSRSPRPSK
PKLSSEELER KRQEMMENAK WREAERLNIL KRHAKDDERE QRLQKLDSRD GKFLHRMKLE
SASTSSLEDR VKRNIYSLQR TSVALEKNFM KR
//