ID I3L638_PIG Unreviewed; 484 AA.
AC I3L638;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Vitronectin {ECO:0000313|Ensembl:ENSSSCP00000019489.3};
GN Name=VTN {ECO:0000313|Ensembl:ENSSSCP00000019489.3,
GN ECO:0000313|VGNC:VGNC:98411};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000019489.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000019489.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000019489.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000019489.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3L638; -.
DR PeptideAtlas; I3L638; -.
DR Ensembl; ENSSSCT00000025790.4; ENSSSCP00000019489.3; ENSSSCG00000027801.4.
DR VGNC; VGNC:98411; VTN.
DR GeneTree; ENSGT00530000063751; -.
DR HOGENOM; CLU_046227_0_0_1; -.
DR TreeFam; TF332780; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000027801; Expressed in liver and 27 other cell types or tissues.
DR ExpressionAtlas; I3L638; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00094; HX; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 2.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR018486; Hemopexin_CS.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF3; VITRONECTIN; 1.
DR Pfam; PF00045; Hemopexin; 3.
DR Pfam; PF01033; Somatomedin_B; 1.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00120; HX; 3.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF50923; Hemopexin-like domain; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS00024; HEMOPEXIN; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 3.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3L638};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..484
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023885195"
FT DOMAIN 20..63
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REPEAT 205..252
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 253..310
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 425..478
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 363..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..400
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 54993 MW; 51AD87DBDAC84D22 CRC64;
MAPLRPLLML ALLAWVALAD QESCKGRCTD GFIAERKCQC DELCSYYQSC CADYVAECKP
QVTRGDVFLQ PDDEYRAYDY HEETRHNTSV QEEPRIPVLL AKTEETPVLK PEEEAPPPGP
QTDDLGVLRK SCAVGNPLMP SPTSRTVPSL PSEVTGMADL GTRVCRRSIL PHTASLPLGL
YCYELDEKAV RPGYPKLIQD VWGIKGPIDA AFTRINCQGK TYLFKGSQYW RFDDGVLDPN
YPREISEGFK GIPDDVDAAL ALPAHSYSGR ERVYFFKGKQ YWEYVFQQQP SREECEGSSP
SDVFAHFALM QRDSWEDIFR LLFWSHSFGG AIEPRIISQD WLGLPEQVDA AMAGQIYISG
SALKPSQPKM TKSARRSGKR YRSRRGRGRG RGHSRSQKSH RQSRSTWLPW FSSEETGPGG
YNYDDYKMDW LVPATCEPIQ SVYFFSGEEY YRVNLRTQRV DTVTPPYPRS IAQYWLGCPV
PDQK
//
