ID I3L778_PIG Unreviewed; 478 AA.
AC I3L778;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Protein phosphatase 1H {ECO:0000256|ARBA:ARBA00044181};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN Name=PPM1H {ECO:0000313|Ensembl:ENSSSCP00000019882.2,
GN ECO:0000313|VGNC:VGNC:91708};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000019882.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000019882.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000019882.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000019882.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PP2C family.
CC {ECO:0000256|ARBA:ARBA00006702}.
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DR AlphaFoldDB; I3L778; -.
DR PaxDb; 9823-ENSSSCP00000025398; -.
DR PeptideAtlas; I3L778; -.
DR Ensembl; ENSSSCT00000029741.3; ENSSSCP00000019882.2; ENSSSCG00000036751.2.
DR VGNC; VGNC:91708; PPM1H.
DR eggNOG; KOG1323; Eukaryota.
DR GeneTree; ENSGT00940000160095; -.
DR HOGENOM; CLU_1656234_0_0_1; -.
DR TreeFam; TF314700; -.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000036751; Expressed in oocyte and 42 other cell types or tissues.
DR ExpressionAtlas; I3L778; baseline and differential.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR015655; PP2C.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR13832:SF287; PROTEIN PHOSPHATASE 1H; 1.
DR PANTHER; PTHR13832; PROTEIN PHOSPHATASE 2C; 1.
DR Pfam; PF00481; PP2C; 2.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3L778};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 77..471
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 109..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 52516 MW; 8E410E265C48EC5C CRC64;
MLTRVKSAVA NFMGGIMAGS SGSEHSGGGC GGSDLPLRFP YGRPEFLGLS QDEVECSADH
IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV LTVKKKAGAI TSTPNRNSAK
RRSSLPNGEG LQLKENSESE GISCHYWSLF DGHAGSGAAV VASRLLQHHV TEQLQDIVEI
LKNSAVLPPT CLGEEPDHTP ANSRTLTRAA SLRGGVGAPG SPGTPPTRFF TEKKIPHECL
VIGALESAFK EMDLQIERER SLYNISGGCT ALIVVCLLGK LYVANAGDSR AIIVRNGEII
PMSSEFTPET ERQRLQYLAF MQPHLLGNEF THLEFPRRVQ RKELGKKMLY RDFNMTGWAY
KTIEDDDLKF PLIYGEGKKV RVYDLSKYEH GADDVLILAT DGLWDVLSNE EVAEAITQFL
PNCDPDDPHR YTLAAQDLVM RARGVLKDRG WRISNDRLGS GDDISVYVIP LIHGNKLS
//