ID I3L7P3_PIG Unreviewed; 534 AA.
AC I3L7P3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=APC membrane recruitment protein 2 {ECO:0000256|ARBA:ARBA00039511};
DE AltName: Full=Protein FAM123A {ECO:0000256|ARBA:ARBA00042108};
GN Name=AMER2 {ECO:0000313|Ensembl:ENSSSCP00000020049.4,
GN ECO:0000313|VGNC:VGNC:85277};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020049.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000020049.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020049.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000020049.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of the canonical Wnt signaling pathway
CC involved in neuroectodermal patterning. Acts by specifically binding
CC phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to
CC the cell membrane and interacting with key regulators of the canonical
CC Wnt signaling pathway, such as components of the beta-catenin
CC destruction complex. {ECO:0000256|ARBA:ARBA00037665}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the Amer family.
CC {ECO:0000256|ARBA:ARBA00007750}.
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DR AlphaFoldDB; I3L7P3; -.
DR STRING; 9823.ENSSSCP00000020049; -.
DR PaxDb; 9823-ENSSSCP00000009916; -.
DR PeptideAtlas; I3L7P3; -.
DR Ensembl; ENSSSCT00000024121.4; ENSSSCP00000020049.4; ENSSSCG00000022678.4.
DR VGNC; VGNC:85277; AMER2.
DR eggNOG; ENOG502QU08; Eukaryota.
DR GeneTree; ENSGT00530000063529; -.
DR InParanoid; I3L7P3; -.
DR TreeFam; TF333006; -.
DR Proteomes; UP000008227; Chromosome 11.
DR Bgee; ENSSSCG00000022678; Expressed in prefrontal cortex and 15 other cell types or tissues.
DR ExpressionAtlas; I3L7P3; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR InterPro; IPR019003; AMER.
DR PANTHER; PTHR22237:SF1; APC MEMBRANE RECRUITMENT PROTEIN 2; 1.
DR PANTHER; PTHR22237; UNCHARACTERIZED; 1.
DR Pfam; PF09422; AMER; 2.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3L7P3};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 55001 MW; 9F8308E6A6B53661 CRC64;
METGGRGAAV SGGRAAAGGC RRKARAAAGT LAADMDLHCD RAAEPPAAEP PSGKINKAAF
KLFKKRKPGG TMPSIFGVKN KGDGKGAGLV RSRTHDGLAE ALVLEGGRRE EPRAGSGDGA
RPGPAAPRAA PGGAGSAAGA SVAKSHSFFS LLRKNGRPES GRAEQADAGP AAGRQKRGLR
GLLGGVRWRR KDRRPKDAAP AGRAGAPGEL ARPGSLTASL ECVKEEAPAA AREPHRPGAD
ARPEPAGCGD IIADPEDEAG PSCAKHAPGP GQPGPAKKPP GVVAYQGGGE EMASPAEADD
SYVQEFWDML SQTEDQGQGP QEGAATAAAA AAPEAQVPPE TPKDARCAEG AKEASSVKRR
RVQRIPAELQ PKEEPKQPDK EPQEGVPNSD EGYWDSTTPG PEEDGARKVG LPRDSDSGDA
LYDLYAEPDG SPAALPAGEE TSCLSRLKPV SPVTVTCPLR TPGSLLKDSK IPISIKHLAN
LPSSHPVVHQ QPARSELPRT KIPVSKVLVR RVSSRGLAGT TLRAAACHDS AKKL
//