ID I3L853_PIG Unreviewed; 1345 AA.
AC I3L853;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSSSCP00000020211.4};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSSSCP00000020211.4,
GN ECO:0000313|VGNC:VGNC:87819};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020211.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000020211.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020211.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000020211.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 9823.ENSSSCP00000020211; -.
DR PaxDb; 9823-ENSSSCP00000026241; -.
DR Ensembl; ENSSSCT00000026533.4; ENSSSCP00000020211.4; ENSSSCG00000024399.4.
DR VGNC; VGNC:87819; EVC2.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR InParanoid; I3L853; -.
DR TreeFam; TF331379; -.
DR Reactome; R-SSC-5632684; Hedgehog 'on' state.
DR Reactome; R-SSC-5635838; Activation of SMO.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000024399; Expressed in adult mammalian kidney and 28 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 826..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 499..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 743..770
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1345 AA; 150667 MW; 49788FD9ED3226EB CRC64;
MPVAVPENFP RRRALSMLGR GAGLGSGSCP NSACTATFGV AGPQPAMGLA GTRGCAAWVL
AGGLLAAALA LPAGPRDRGR PPTGPNPLQR PLGAQLPPDP PAAPGAGPER EAQDLPRVTW
PLPESAPFQS AVEAPFGMTF NKKVEAFHLP LTSAASGGPH IHSPLAFLPS WPKILLKRES
ASIHRLHGDT SRDLQGTSEN GVIFQKCAVV TGQSEWPVVH VQLLVHNTRA PSATNLSDLL
LLDNVTGLSV RESAGNQTSR GFQAFRKKFL QVGDSFSVQY TAWLEAGGVG SGEVLMLPAL
LSFQTSSPNR TQLKALLTIT TDEKITVLPN HGLHAMGFFV ALILSLLLTW AVLFFMVRYQ
CLKGSLLSRH RVRHHEDKLE HSQFTSADGV NEDLALNEQM IDILSSEDPG SMLPALEELE
IATLNRADSD LEACRTQISK DIIALLLKNL TSSGHLSPQG ARRMDAIFQK QFLWLEKEIQ
EEYDRKMVAL TAECDLDTRK KTESQYQREM AAMEEAEEVL KRGSERSAAE CSSLLRTLHG
LEQEHLRRSL ALQQEEDFAK AHRQLAIFQR SELHSIFFTQ IQSAIFKGEL KPEAAKMLLQ
DYSKIQERIE ELMDFFQASK RYHLSKRFGH REYLVQSLQS LETRVQGLLS TASAQLSLLI
QKHERAGYLD EDQMEVLLER VQTEVFSIKQ KLDNDLKQER KKLHQKLITK RRREMLQKHK
EQRKEQLSIG EALGAAEDAG QYLGQWRSLV AEHSAALEEL QERLDQAALD ELRALTLSLS
EKATEELRRL QNSAMTQELL KLGVPWLFLQ PILEEHSRDL AARAERLEGE ERDRGQEGVQ
SVRQRLKDDA LEASTEEQAE LRHWEHLIFG QLCSSALSLS EEELLRMRQE VHGCFAQMDR
SLALPQIRAR VLLQAFQTAW REAEFLKLDQ ALAAPELQPQ SKVRKPRSKT KSKIDLFKKC
IEEKIQLFKE QAPEDLLEKV RGELLRERVQ QLEAQEGHFA ESLVSLQFQK AARRARTLWA
YTALLTVQDL LLQELSASET LTKSACAQIL ESHSPELQEL ERKLEDQLAH QEAAKLQRVL
ASRQQWAGEE PGLLHQPEET DSERQISAVL QRALSKGQKV LEHRQQSLRE EQEDSVVLED
VLGNMEMDAF VTLYGQELRL ASYLSKLAML PGGTLRRLLS VALPAASQPE LLALLDSFGQ
KHQEHAVEND GGAGQADLGR RRKHQGWWQA LESKLRGELL SRGADKMLWA HKRKESILKR
TCLPLTERVT FSGKGRWPHL SLESIGDLAP VPIVGAEAVD VLNTGEKLFI FRSPTEPEIS
LHLPPRKKKK SFLNAKKAAW ALGMN
//