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Database: UniProt
Entry: I3L853_PIG
LinkDB: I3L853_PIG
Original site: I3L853_PIG 
ID   I3L853_PIG              Unreviewed;      1345 AA.
AC   I3L853;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2022, sequence version 4.
DT   24-JAN-2024, entry version 62.
DE   SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSSSCP00000020211.4};
GN   Name=EVC2 {ECO:0000313|Ensembl:ENSSSCP00000020211.4,
GN   ECO:0000313|VGNC:VGNC:87819};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020211.4, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000020211.4, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020211.4,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000020211.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
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DR   STRING; 9823.ENSSSCP00000020211; -.
DR   PaxDb; 9823-ENSSSCP00000026241; -.
DR   Ensembl; ENSSSCT00000026533.4; ENSSSCP00000020211.4; ENSSSCG00000024399.4.
DR   VGNC; VGNC:87819; EVC2.
DR   eggNOG; ENOG502QQ5U; Eukaryota.
DR   GeneTree; ENSGT00940000154127; -.
DR   HOGENOM; CLU_007621_0_0_1; -.
DR   InParanoid; I3L853; -.
DR   TreeFam; TF331379; -.
DR   Reactome; R-SSC-5632684; Hedgehog 'on' state.
DR   Reactome; R-SSC-5635838; Activation of SMO.
DR   Proteomes; UP000008227; Chromosome 8.
DR   Bgee; ENSSSCG00000024399; Expressed in adult mammalian kidney and 28 other cell types or tissues.
DR   GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   InterPro; IPR022076; Limbin.
DR   InterPro; IPR026501; Limbin/EVC.
DR   PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR   PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR   Pfam; PF12297; EVC2_like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        56..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          826..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          499..526
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          743..770
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1345 AA;  150667 MW;  49788FD9ED3226EB CRC64;
     MPVAVPENFP RRRALSMLGR GAGLGSGSCP NSACTATFGV AGPQPAMGLA GTRGCAAWVL
     AGGLLAAALA LPAGPRDRGR PPTGPNPLQR PLGAQLPPDP PAAPGAGPER EAQDLPRVTW
     PLPESAPFQS AVEAPFGMTF NKKVEAFHLP LTSAASGGPH IHSPLAFLPS WPKILLKRES
     ASIHRLHGDT SRDLQGTSEN GVIFQKCAVV TGQSEWPVVH VQLLVHNTRA PSATNLSDLL
     LLDNVTGLSV RESAGNQTSR GFQAFRKKFL QVGDSFSVQY TAWLEAGGVG SGEVLMLPAL
     LSFQTSSPNR TQLKALLTIT TDEKITVLPN HGLHAMGFFV ALILSLLLTW AVLFFMVRYQ
     CLKGSLLSRH RVRHHEDKLE HSQFTSADGV NEDLALNEQM IDILSSEDPG SMLPALEELE
     IATLNRADSD LEACRTQISK DIIALLLKNL TSSGHLSPQG ARRMDAIFQK QFLWLEKEIQ
     EEYDRKMVAL TAECDLDTRK KTESQYQREM AAMEEAEEVL KRGSERSAAE CSSLLRTLHG
     LEQEHLRRSL ALQQEEDFAK AHRQLAIFQR SELHSIFFTQ IQSAIFKGEL KPEAAKMLLQ
     DYSKIQERIE ELMDFFQASK RYHLSKRFGH REYLVQSLQS LETRVQGLLS TASAQLSLLI
     QKHERAGYLD EDQMEVLLER VQTEVFSIKQ KLDNDLKQER KKLHQKLITK RRREMLQKHK
     EQRKEQLSIG EALGAAEDAG QYLGQWRSLV AEHSAALEEL QERLDQAALD ELRALTLSLS
     EKATEELRRL QNSAMTQELL KLGVPWLFLQ PILEEHSRDL AARAERLEGE ERDRGQEGVQ
     SVRQRLKDDA LEASTEEQAE LRHWEHLIFG QLCSSALSLS EEELLRMRQE VHGCFAQMDR
     SLALPQIRAR VLLQAFQTAW REAEFLKLDQ ALAAPELQPQ SKVRKPRSKT KSKIDLFKKC
     IEEKIQLFKE QAPEDLLEKV RGELLRERVQ QLEAQEGHFA ESLVSLQFQK AARRARTLWA
     YTALLTVQDL LLQELSASET LTKSACAQIL ESHSPELQEL ERKLEDQLAH QEAAKLQRVL
     ASRQQWAGEE PGLLHQPEET DSERQISAVL QRALSKGQKV LEHRQQSLRE EQEDSVVLED
     VLGNMEMDAF VTLYGQELRL ASYLSKLAML PGGTLRRLLS VALPAASQPE LLALLDSFGQ
     KHQEHAVEND GGAGQADLGR RRKHQGWWQA LESKLRGELL SRGADKMLWA HKRKESILKR
     TCLPLTERVT FSGKGRWPHL SLESIGDLAP VPIVGAEAVD VLNTGEKLFI FRSPTEPEIS
     LHLPPRKKKK SFLNAKKAAW ALGMN
//
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