ID   I3L9X6_PIG              Unreviewed;       918 AA.
AC   I3L9X6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Death domain containing 1 {ECO:0000313|Ensembl:ENSSSCP00000020840.2};
DE   SubName: Full=Death domain-containing protein 1 isoform X2 {ECO:0000313|EMBL:HCZ75470.1};
GN   Name=DTHD1 {ECO:0000313|Ensembl:ENSSSCP00000020840.2,
GN   ECO:0000313|VGNC:VGNC:98920};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020840.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000020840.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020840.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:HCZ75470.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000020840.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; DQIR01019995; HCZ75470.1; -; Transcribed_RNA.
DR   STRING; 9823.ENSSSCP00000020840; -.
DR   PaxDb; 9823-ENSSSCP00000020840; -.
DR   Ensembl; ENSSSCT00000028675.4; ENSSSCP00000020840.2; ENSSSCG00000028471.4.
DR   VGNC; VGNC:98920; DTHD1.
DR   eggNOG; ENOG502QTTM; Eukaryota.
DR   GeneTree; ENSGT00940000153404; -.
DR   HOGENOM; CLU_013631_0_0_1; -.
DR   OMA; KENQCTW; -.
DR   OrthoDB; 5312372at2759; -.
DR   TreeFam; TF351910; -.
DR   Proteomes; UP000008227; Chromosome 8.
DR   Bgee; ENSSSCG00000028471; Expressed in lung and 12 other cell types or tissues.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR28336; BA1-643; 1.
DR   PANTHER; PTHR28336:SF4; DEATH DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00531; Death; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          427..598
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          822..886
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          188..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          896..918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..214
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   918 AA;  104164 MW;  07A984E203699ED1 CRC64;
     MDTEDIGSGK LGQILKQIWR QNVMLKQALL GEDHCEGAGG ATWIATVVFL GQGLSRALHQ
     LLEHIAGTLR STCQQLCVLL DKENHCTWTQ EIVTFRECLM KINEYLGGTA AFLKKEEKEM
     CNLCGMHDEC APQQTMSAIQ DIKATDIAAR EEQNVIETAT VSPTSREESH YPNQVQLKKN
     KTYRSSELVE KENNTSLNGD VTGQEESQNK MFPDNTENEN DKQTEHMTVE NINGNRRETH
     DIIQTTEREI QETSESQREE MIISSITCDI TNKYVTSLLP SDPESLKQKE NIMEKEYLDV
     LNDNTLPQVS CYITAPSSVL QHLECRIINS MSSLVVSDNE ELVSNVITVE CSEMEKRIPF
     PICIAIPFTA RYRGNYRDIM VKVSDINFQS SYLTPNSLEG MRGSYKGTYA EVKVYKLGIF
     SVVSCLKKES FTVTKKGLTL KPSMDSRISL NYPPGVFSSP VLIQLKVQPI DPSLVAYLKT
     QQDISYSVLS TSPVIHIQHP STHPFQKPVT VFLPCSPHPD KKNLGSEVDH KGRASTTANR
     IIPLYLNWTK RTSIRKPGNT CESLKLLGFR SRDSGWFVLD GVMVRTTQSG LISFELCEHL
     ERFIVLRLSS IMENSHLLSF VKSLEEAMFS TTACIVLYHQ KDNPHRVVIL VVPSKDLNQE
     LRHLRLGGLS GPPEPSRHFQ VKEGEQLLLR FTGNIFASSN GKDYGKDYKL IFHLQRKPRL
     ELQIKEVDEF GNYSCPHYKG TIIVYKVPKE KIVHNSDQCL ILNENNYQLP ICKLPLRLPK
     HENLINRPQS TKRISTDPLE ALWNSLLYWL SEELSEENAL CLSASLPLRR STVQLIKLKA
     PNDLAEQTYE LLCFWKRSLP NSTDKLRLLA RHLRKIGRSD LSGELKFKWE NKVFTEPPRW
     SDGAEESPVA PSALEEGL
//