ID I3LA49_PIG Unreviewed; 968 AA.
AC I3LA49;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 5 {ECO:0000313|Ensembl:ENSSSCP00000020915.2};
GN Name=HERC5 {ECO:0000313|Ensembl:ENSSSCP00000020915.2,
GN ECO:0000313|VGNC:VGNC:88850};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020915.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000020915.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020915.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000020915.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3LA49; -.
DR SMR; I3LA49; -.
DR STRING; 9823.ENSSSCP00000020915; -.
DR PeptideAtlas; I3LA49; -.
DR Ensembl; ENSSSCT00000030140.3; ENSSSCP00000020915.2; ENSSSCG00000030548.4.
DR VGNC; VGNC:88850; HERC5.
DR GeneTree; ENSGT00940000162703; -.
DR HOGENOM; CLU_002173_9_2_1; -.
DR InParanoid; I3LA49; -.
DR OMA; KHKAYLM; -.
DR TreeFam; TF315189; -.
DR Reactome; R-SSC-1169408; ISG15 antiviral mechanism.
DR Reactome; R-SSC-936440; Negative regulators of DDX58/IFIH1 signaling.
DR Reactome; R-SSC-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Reactome; R-SSC-9833482; PKR-mediated signaling.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000030548; Expressed in blood and 43 other cell types or tissues.
DR ExpressionAtlas; I3LA49; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0042296; F:ISG15 transferase activity; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0032020; P:ISG15-protein conjugation; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF7; E3 ISG15--PROTEIN LIGASE HERC5; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 4.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 4.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LA49};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 101..153
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 154..205
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 206..257
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 259..321
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 646..968
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 938
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 968 AA; 109448 MW; 4F9B7619B1A5B9D2 CRC64;
MCCTGGRLAV LERGGAGVEV HQLPAGSDGA RKPKCIKLGK KMKIHSMDQG AEHMLILSSD
GKPFEYNYSI EHARFQCILQ EKIIIQITCG DYHSLALSKG GELFAWGENL HGQLGVGRGI
ASTPTPQMVE HLYGVPLAQV SAGGAHSVAL SMSGNVYSWG GNDFGQLGLG HTDDADFPSR
IEALDGQHVE FLACGASHTA LLTKGGLVLT FGDGRCGQLG HNSTQNELRP RLVTELVGKR
VTQMACGREH TLAYVSDLGK VFAFGSGTEG QLGNGGTHNQ LIPRPMKLPS NEELKFESRT
SEKELIMIAG GNQSILLWME KENSYVNLRR KIPTLNEGTV KRWLADVGTK QWQNTKREIR
EIFSSPACLT GSFLRERITG GRTSVHLDLN TARTALSELA RKDCITNTIT ACLRENLLKA
LPCHSPHREA VEVFFLLPEC PVMHDDNNWE SLVVPFAEAV GKMSDPSSGV LEEYWASLGE
SAFIRLVQMF KRAIVAQLRC WTKSAESNCH IKALLELLKK LHRVNQTKCH LPESIFTVNE
LTDYLDFHED AYRRSFWKVS SDTSVDIQYP VIFSHFPFIF NILSKIKLLY ADSLLKIQQK
KIRAYMPLAG ILGQEGSELA LPPTLNLLVR RGHLIEDVFS HLSRYENEDL RRELLVSFSG
EIGYDFGGVR AEFFHCLFEE LTQPEYGLFT YPEDASCMWF PARPKFENKS YFFFGILCGL
SLFNCNVANI PFPLALFKKL LDQEPSLEDL KELSPVLGQS LQTLLDYEDD DFGKIFHVHF
NMHWDKDSVD LIPHGSDVIV DQSNKREYIS KYVDYIFNIS VKEVYEEFQR GFYRVCDKEI
IEFFHPEELK DVIIGNTDYD WETFEKNARY EHGYDNSHPT IVMFWKALHK LTLEEKKKFL
VFLTGTDRIQ VRGLKNMKIT FCCPENMNEK DPIRAQTCFS VLYLPKYSTM ERVEEALQVA
ISNHRGFG
//
