ID I3LAK6_PIG Unreviewed; 1161 AA.
AC I3LAK6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=ALF transcription elongation factor 1 {ECO:0000313|Ensembl:ENSSSCP00000021074.4};
GN Name=AFF1 {ECO:0000313|Ensembl:ENSSSCP00000021074.4,
GN ECO:0000313|VGNC:VGNC:85167};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000021074.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000021074.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000021074.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000021074.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR AlphaFoldDB; I3LAK6; -.
DR STRING; 9823.ENSSSCP00000021074; -.
DR Ensembl; ENSSSCT00000031231.4; ENSSSCP00000021074.4; ENSSSCG00000023593.4.
DR VGNC; VGNC:85167; AFF1.
DR GeneTree; ENSGT00950000182974; -.
DR HOGENOM; CLU_006484_1_0_1; -.
DR InParanoid; I3LAK6; -.
DR TreeFam; TF326216; -.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000023593; Expressed in oocyte and 42 other cell types or tissues.
DR ExpressionAtlas; I3LAK6; baseline and differential.
DR GO; GO:0032783; C:super elongation complex; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF6; AF4_FMR2 FAMILY MEMBER 1; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 902..1160
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..233
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 124099 MW; 58A5A64223FC43F8 CRC64;
MLGNYEEMKE FLSTKSHSQR LDASEHRLGK PRYPLLPEKG SGIPSHSFHP SLHHQPGNTP
ASGPLPVGTI SQNPKMAQPR MEPVPSLQGK SYGPPDGPLL PQDRLAPEGY GSSQHKKRER
RADGDHGALM PDPAPERELA PLFALPSPVP PLSPVHSNQQ TLPRMQGSSK GHSSSSSSSS
KGYGPGKSPK DLAGKVPEKE TPQEPSGATA GLGGAPPPPP SQTFPPPPLP SKSLAMQQKP
TAYVRPMDGQ DQAPSESPEL KPLPEDFRQQ TFEKTDLKVP AKTKLTKLKM PAQSVEQTYS
NEVHCVEEIL KEMTHSWPPP LTAIHTPGTA EPSKFPFPTK DSQHISSATQ NQKQYDTSSK
PHSNPQQGTS MLRDDLQLSD SEDSDGDQTP EKPPSASAPP SAPPPPPPPP PPPPPPPEAA
SAHSSSAESE STSDSDSSSD SESESSSSDS EENEPQEAPA PPEPEPPTTN KWQLDNWLTK
VSQPPVPAEA PGSAEPPPRH ADNKGKGGDS APAGHERSES KEPAPKSSSR GPRGPSEGPH
SGKRTCQKSP AQQEPPQRQT VGTKQPKKPA KPSAPADARA CVQAESQLGS KDQPSKDKPK
VKTKGRPRAG ESCEPKPPAP APAPGPGERK KHRSGPADPP KAPPKEAAED GSPDHFALVP
LTQSQGPARG GARTSGCRLA VVVQEDRRKD RPPGPSRDTK LLSPLRDTPP PQSLMVKITL
DLLSRVPQPP GKASRPKKPE DKPPVAAKKP DPEKRSSDPA SKLAKKRKGE SERDHESKKT
RLEKEIKSQS SASSSHKEPS KSKTPRPSSE PSKKEPLPPP LVSSSSSQKP AKPAQKRPRQ
EADACGQDPP KSASSSKGIH KDSSVSKHRK VDGKGSGSST EHRGSSGDTA NRFPVPCLPN
GNSKPGKPHV KSDKQQADFH MKEAKRLKDK AELVTDKVGK AFKYLEAALA FIECGIAVES
ESPASRSAYS IYSETLDLIK SIMSLKSFSD ATTPTQEKIF AVLCMRCQSI LNMAMFRCKK
DIAIKYSRTL NEHFFKTSSR VAQAPSPCIA RSTGTPSPLS PTPSPAGSLG SQSGAGGGMP
AAVSTPVTIQ NMTSSYVSIT SHVLTAFDLW EQAEVLIKKN KEFFAQLSTS VCALALNSSL
MDLVHYTRQG FQRLKQVTKT P
//
