ID I3LE77_PIG Unreviewed; 196 AA.
AC I3LE77;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=High mobility group box 4 {ECO:0000313|Ensembl:ENSSSCP00000022363.2};
GN Name=HMGB4 {ECO:0000313|Ensembl:ENSSSCP00000022363.2,
GN ECO:0000313|VGNC:VGNC:88903};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000022363.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000022363.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000022363.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000022363.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3LE77; -.
DR SMR; I3LE77; -.
DR STRING; 9823.ENSSSCP00000022363; -.
DR PaxDb; 9823-ENSSSCP00000022363; -.
DR Ensembl; ENSSSCT00000022862.2; ENSSSCP00000022363.2; ENSSSCG00000021247.2.
DR VGNC; VGNC:88903; HMGB4.
DR eggNOG; KOG0381; Eukaryota.
DR GeneTree; ENSGT00940000162735; -.
DR HOGENOM; CLU_082854_0_4_1; -.
DR InParanoid; I3LE77; -.
DR OMA; MWSAKTD; -.
DR TreeFam; TF105371; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000021247; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd21978; HMG-box_HMGB_rpt1; 1.
DR CDD; cd21979; HMG-box_HMGB_rpt2; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR48112:SF7; HIGH MOBILITY GROUP PROTEIN B4; 1.
DR PANTHER; PTHR48112; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; HMG-box; 2.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 9..79
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 93..161
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 9..79
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT DNA_BIND 93..161
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 77..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 196 AA; 22781 MW; 568C0B0BF88E1C7F CRC64;
MGKEIQLKPK ANVSSYIHFL LNYRNKFKEQ QPNTYLGFKE FSRKCSEKWR SISKHEKAKY
EALAKLDKAR YQEEMRNYVG GKRKRRKRDP QAPRRPPSSF LLFCQDNYAQ LKRENPNWSV
AQVAKASARM WSTTTDVDKQ PYEQRAALLR AKYHEELSVY QKQFNGSKKS PQGVAPIQGK
GLGQTESDIA DGSNQK
//
