ID I3LEE6_PIG Unreviewed; 470 AA.
AC I3LEE6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Procollagen C-endopeptidase enhancer {ECO:0000313|EMBL:HDA39962.1, ECO:0000313|Ensembl:ENSSSCP00000022434.1};
GN Name=PCOLCE {ECO:0000313|Ensembl:ENSSSCP00000022434.1,
GN ECO:0000313|VGNC:VGNC:91227};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000022434.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000022434.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000022434.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA39962.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000022434.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; DQIR01084486; HDA39962.1; -; Transcribed_RNA.
DR EMBL; DQIR01087861; HDA43337.1; -; Transcribed_RNA.
DR EMBL; DQIR01270136; HDC25614.1; -; Transcribed_RNA.
DR EMBL; DQIR01323783; HDC79257.1; -; Transcribed_RNA.
DR RefSeq; XP_003354522.1; XM_003354474.3.
DR STRING; 9823.ENSSSCP00000022434; -.
DR PaxDb; 9823-ENSSSCP00000022434; -.
DR Ensembl; ENSSSCT00000029137.3; ENSSSCP00000022434.1; ENSSSCG00000027466.3.
DR GeneID; 100627524; -.
DR KEGG; ssc:100627524; -.
DR CTD; 5118; -.
DR VGNC; VGNC:91227; PCOLCE.
DR eggNOG; ENOG502QTZ9; Eukaryota.
DR GeneTree; ENSGT00940000159264; -.
DR HOGENOM; CLU_034096_0_0_1; -.
DR OMA; WDEHQFC; -.
DR OrthoDB; 5355450at2759; -.
DR TreeFam; TF316506; -.
DR Reactome; R-SSC-1650814; Collagen biosynthesis and modifying enzymes.
DR Reactome; R-SSC-2243919; Crosslinking of collagen fibrils.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000027466; Expressed in subcutaneous adipose tissue and 42 other cell types or tissues.
DR Genevisible; I3LEE6; SS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005518; F:collagen binding; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0016504; F:peptidase activator activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00041; CUB; 2.
DR CDD; cd03576; NTR_PCOLCE; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035814; NTR_PCOLCE.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR PANTHER; PTHR24251:SF24; PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 1; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00042; CUB; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50189; NTR; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LEE6};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..470
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158212"
FT DOMAIN 37..149
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 159..273
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 339..458
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 272..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 159..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 470 AA; 49991 MW; 60D8C4AF9F743AD0 CRC64;
MLPAATASLL GPLLTAWALL PFAQGQTPNY TRPVFLCGGD VTGESGYLAS EGFPNLYPPN
KECIWTITVP ESQTVSLSFR VFDLELHPSC RYDALEVFAG SGTSGQRLGR FCGTFRPAPL
VAPGNQVTLR MTSDEGTGGR GFLLWYSGRA TSGTEHQFCG GRLEKAQGTL TTPNWPESDY
PPGISCSWHI IAPPDQVISL TFGKFDLEPD SYCRYDSVSV FNGAVSDDAK RLGKFCGDKA
PGPISSEGNE LLVQFVSDLS VTADGFSASY RTLPRGATEK APAQSPGEDA RPSPPLLGPG
PKPGAGPKVK PELPPEEKPK AAPKAEATPA GSDGPSVPCP KQCRRTGTLQ SNFCNSNLVV
TATVKSMVRG PGEGLTVTVS LIGVYKTGGL DLPSPPTDTS LKFYAPCKQC PPMKKGTSYL
MMGQVDENRG PILPPESFVV LYRPNQDQIL TNLAKRRCPS QPVQAAESQA
//
