ID I3LEQ9_PIG Unreviewed; 1062 AA.
AC I3LEQ9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase B {ECO:0000313|Ensembl:ENSSSCP00000022548.3};
DE SubName: Full=Mitotic checkpoint serine/threonine-protein kinase BUB1 beta {ECO:0000313|EMBL:HDA40359.1, ECO:0000313|EMBL:HDB70326.1};
GN Name=BUB1B {ECO:0000313|Ensembl:ENSSSCP00000022548.3,
GN ECO:0000313|VGNC:VGNC:103039};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000022548.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000022548.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000022548.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA40359.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000022548.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; DQIR01084883; HDA40359.1; -; Transcribed_RNA.
DR EMBL; DQIR01214849; HDB70326.1; -; Transcribed_RNA.
DR EMBL; DQIR01257701; HDC13179.1; -; Transcribed_RNA.
DR PaxDb; 9823-ENSSSCP00000005153; -.
DR Ensembl; ENSSSCT00000031444.4; ENSSSCP00000022548.3; ENSSSCG00000004782.5.
DR VGNC; VGNC:103039; BUB1B.
DR GeneTree; ENSGT00940000158912; -.
DR HOGENOM; CLU_1017576_0_0_1; -.
DR OrthoDB; 5479089at2759; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000004782; Expressed in oocyte and 29 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0033597; C:mitotic checkpoint complex; IEA:Ensembl.
DR GO; GO:0000940; C:outer kinetochore; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005819; C:spindle; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0071459; P:protein localization to chromosome, centromeric region; IEA:Ensembl.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR PANTHER; PTHR14030:SF25; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 BETA; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:HDA40359.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transferase {ECO:0000313|EMBL:HDA40359.1}.
FT DOMAIN 63..226
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 707..1062
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 432..469
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1062 AA; 120880 MW; DA3F842B64F75572 CRC64;
MAAMQKGSGV PSEVTSLEGD EWELSKENVQ PLRQGRIMST LQGALAQQES TCNTTLQQQK
RAFESEIRFY AGNDPLDVWD RYINWTEQNY PQGGKESNMS TLLERAIEAL QGEKRYYNDP
RFLSLWLKLG HLCNEPLDMY SYLHNQGIGI SLAQFYISWA EEYEARENFK KADMIFQEGI
QQKAEPMERL QSQHRHFQAR VSRQTLLALE KEEDEAFGSS VPQRSTLAEL KSKGKKTARV
PISRVGGALK APNQNRGLQN PVPQQMQSNS RITIFDENAE EASRAEASKP TVQPWIAPPI
PRAKENELQA GPWNTGRPLE YRPRGNTASM TAVPSMLPSF TPYVEETAQQ PVMTPCKIEP
SINHILSTRK PGKEEADLLQ RVQNHQQESE EKKEKIMYCK EKIYAGVGEF SFEEIRAEVF
RKKLKEQREA ELLTSAKKRA EMQKQIEEME KKLKEIQTTQ QERASDQQEE KMSTKETAEL
RIASESQEIP ALSLSNSAYP VNACARETSL AENIWQEQPC SQSSSVPFSI FDEFLLSEKK
TISPSADPPR VLAQRRPLAI LKTLESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT
ICPNPEDTCD FARAAHFAST PFHEMICLKD LPSDSKRQLQ EEDLDVKTSE DQQTACGTIY
NPTLSIKKLS PIIEDSREAT HSSGFSGSSA SVTSTSSIKC LQIPEKLELT NETADGPPQS
PWCSQYRRQL LKSLPELTAS AEFFIEDRPM PNLEIEKEIE LDNEDYCIIQ EYLTCEDYKL
FWVTPRNSAE LTIIKVSSQP VLWDFYINLK LKERLNEECD NLCSCYQYQD GCIIWHQYIN
CFTIQDLLQH SEFITHEMTV LIIYNLLTIV EKLHKAEIVH GDLSPRSLIL RNRIHDPYDC
DKNNQALKIV DFSYSVDLRA QLDVFNLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA
HLLLFKEHLQ VFWDGSLWKL SQNISELKDG ELWNKFFVRI LNASDESTVS VLRELAAEMN
GVFDTTFQSH LNKALWKVGT LISPGALLFQ QDRQSSLSQI PA
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