ID I3LF61_PIG Unreviewed; 524 AA.
AC I3LF61;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Docosahexaenoic acid omega-hydroxylase CYP4F3-like {ECO:0008006|Google:ProtNLM};
GN Name=LOC110255237 {ECO:0000313|Ensembl:ENSSSCP00000022701.4};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000022701.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000022701.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000022701.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000022701.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR AlphaFoldDB; I3LF61; -.
DR STRING; 9823.ENSSSCP00000022701; -.
DR PeptideAtlas; I3LF61; -.
DR Ensembl; ENSSSCT00000030903.4; ENSSSCP00000022701.4; ENSSSCG00000027013.4.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00940000155021; -.
DR HOGENOM; CLU_001570_5_1_1; -.
DR InParanoid; I3LF61; -.
DR OrthoDB; 1611592at2759; -.
DR TreeFam; TF105088; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000027013; Expressed in psoas major muscle and 35 other cell types or tissues.
DR ExpressionAtlas; I3LF61; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20679; CYP4F; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF141; CYTOCHROME P450 CYP4F13-RELATED; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..524
FT /note="Docosahexaenoic acid omega-hydroxylase CYP4F3-like"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093963"
SQ SEQUENCE 524 AA; 60527 MW; 7A6CBD3C29DD1CD7 CRC64;
MLQLSLSWLG LGPVSASPWL LLQLVGATWL LSRILSWIYD FYDNCCRLRC FPQPPKRNWF
WGHWDLAKSN EEGLQLIEDM GRLFCDVYLW WLGPFYPILR LVHPNFVAPL LQAPATIIPK
DMLFYSFLKP WLGVGLLLSA GEKWSHQRRL LTPAFHFDIL KSYVKIFNRS ADIMHAKWQR
LASEGHTRLD MFEHISLMTL DSLQKCVFSF DSNCQEKPSE YITAILALSA LVIKRCEQIF
LHKDFLYYLT PEGRRFRKAC RLVHDFTDAV IQERRCTLIS QGSQDFLRAK AKAKTLDFID
VLLLAKDEDG KGLSDEDIRA EADTFMFAGH DTTASGLSWV LYNLAKHPEY QERCRKEVQE
LLRDREPKEI EWDELAQLPF LTMCIKESLR LHPPVPGISR CCAQDVVLPD GRVIPKGNIC
VISIFGIHHN PSVWPDPEVY NPFRFDPESP QKRSPLAFIP FSAGPRNCIG QTFAMTEMKV
VLALTLLRFR VLPDEEEPRR KPEIVLRAEG GLWLRVEPLR GGQQ
//
