ID I3LGA2_PIG Unreviewed; 396 AA.
AC I3LGA2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Lysophosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00015438};
DE EC=3.1.1.23 {ECO:0000256|ARBA:ARBA00013254};
DE AltName: Full=2-arachidonoylglycerol hydrolase ABHD12 {ECO:0000256|ARBA:ARBA00033386};
DE AltName: Full=Abhydrolase domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032497};
DE AltName: Full=Monoacylglycerol lipase ABHD12 {ECO:0000256|ARBA:ARBA00030575};
DE AltName: Full=Oxidized phosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00030502};
GN Name=ABHD12 {ECO:0000313|Ensembl:ENSSSCP00000023095.3,
GN ECO:0000313|VGNC:VGNC:95682};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000023095.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000023095.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000023095.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA55449.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000023095.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.;
CC EC=3.1.1.23; Evidence={ECO:0000256|ARBA:ARBA00001613};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the serine esterase family.
CC {ECO:0000256|ARBA:ARBA00006584}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01099973; HDA55449.1; -; Transcribed_RNA.
DR EMBL; DQIR01205113; HDB60590.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000023095; -.
DR ESTHER; pig-i3lga2; ABHD12-PHARC.
DR PaxDb; 9823-ENSSSCP00000023095; -.
DR Ensembl; ENSSSCT00000030598.3; ENSSSCP00000023095.3; ENSSSCG00000040449.3.
DR VGNC; VGNC:95682; ABHD12.
DR GeneTree; ENSGT00940000160517; -.
DR HOGENOM; CLU_029375_1_0_1; -.
DR OMA; VEFHRFE; -.
DR OrthoDB; 47056at2759; -.
DR TreeFam; TF315122; -.
DR Reactome; R-SSC-426048; Arachidonate production from DAG.
DR Proteomes; UP000008227; Chromosome 17.
DR Bgee; ENSSSCG00000040449; Expressed in prefrontal cortex and 43 other cell types or tissues.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR GO; GO:0004622; F:lysophospholipase activity; IBA:GO_Central.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:Ensembl.
DR GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR GO; GO:0052651; P:monoacylglycerol catabolic process; IBA:GO_Central.
DR GO; GO:0006660; P:phosphatidylserine catabolic process; IBA:GO_Central.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF61; LYSOPHOSPHATIDYLSERINE LIPASE ABHD12; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LGA2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 169..274
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 396 AA; 44632 MW; B2C59135FAEDD6F4 CRC64;
MRKRAEPVAL EHERRAVSGS PSAGSAASAL DADCRLKQNL CLAGPGPAEP RCASDAGMKR
ALGRRKGLCF RLRKILLCVL GLYVAIPFLI KLCPAIQAKL IFLNFVRVPY FIDLKKPQDQ
GLNHTCNYYL HPEEGVTIGV WHTVPAVWWK NAQGKDQIWY EDALASSRPI ILYLHGNAGT
RGGDHRVELY KVLSSLGYHV VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV
YIWGHSLGTG VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
FLDPITSSGI QFANDENVKH ISCSLLILHA EDDPVVPFQL GRKLYSIAAP SRSFRDFKVQ
FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPAA
//
