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Database: UniProt
Entry: I3LGI9_PIG
LinkDB: I3LGI9_PIG
Original site: I3LGI9_PIG 
ID   I3LGI9_PIG              Unreviewed;       650 AA.
AC   I3LGI9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   13-FEB-2019, entry version 53.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   Name=GLB1 {ECO:0000313|Ensembl:ENSSSCP00000023183};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000023183, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000023183}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000023183};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RG   Swine Genome Sequencing Consortium;
RA   Drou N., Caccamo M.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000023183}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [4] {ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RG   International Swine Genome Sequencing Consortium;
RA   Warr A., Hall R., Kim K., Koren S., Phillippy A.M., Bickhart D.M.,
RA   Rosen B., Schroeder S., Hume D.A., Talbot R., Chow W., Howe K.,
RA   Nonneman D.J., Rohrer G.A., Watson M., Smith T.P., Archibald A.L.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RA   Warr A., Hall R., Kim K., Koren S., Phillippy A.M., Bickhart D.M.,
RA   Rosen B., Schroeder S., Hume D.A., Talbot R., Chow W., Howe K.,
RA   Nonneman D.J., Rohrer G.A., Watson M., Smith T.P., Archibald A.L.;
RT   "Exploiting long read sequencing technologies to establish high
RT   quality highly contiguous pig reference genome assemblies.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; AEMK02000085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000023183; -.
DR   PaxDb; I3LGI9; -.
DR   PeptideAtlas; I3LGI9; -.
DR   PRIDE; I3LGI9; -.
DR   Ensembl; ENSSSCT00000028253; ENSSSCP00000023183; ENSSSCG00000024119.
DR   eggNOG; KOG0496; Eukaryota.
DR   eggNOG; COG1874; LUCA.
DR   GeneTree; ENSGT00390000006586; -.
DR   InParanoid; I3LGI9; -.
DR   Reactome; R-SSC-1660662; Glycosphingolipid metabolism.
DR   Reactome; R-SSC-4085001; Sialic acid metabolism.
DR   Reactome; R-SSC-6798695; Neutrophil degranulation.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Bgee; ENSSSCG00000024119; Expressed in 5 organ(s), highest expression level in lung.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR   GO; GO:0004565; F:beta-galactosidase activity; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:Ensembl.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:I3LGI9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    650       Beta-galactosidase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5012000043.
FT   DOMAIN       42    343       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      538    606       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    175    175       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    255    255       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   650 AA;  73432 MW;  BED0FF54EC6C2661 CRC64;
     TCPHPWVTGH LLMLWKFSCG LVLALQNAPL RTFKIDYNRN CFLKDGQPFR YISGSIHYFR
     MPRFYWKDRL LKMKMAGLNA IETYVAWNFH EPWPGKLAHQ LGLLVILRPG PYICAEWDMG
     GLPAWLLEKE SIVLRSSHPD YLAAVDKWLG VLLPKMKPLL YQNGGPIITV QVENEYGSYY
     SCDYNYLRFL QKRFHYYLGE DVVLFTTDGA HEKFLACGTL EGLYATVDFG VDANITAAFL
     MQRKYEPRGP LINSEFYTGW LDHWGQPHST VKTQVVASFL HDILALGANV NMYMFIGGTN
     FAYWNGANTP YQPQPTSYDY DAPLSEAGDL TEKYFALRDV IQKFKKVPEG LIPPSTPKFA
     YGKVALKKLK TVVEALDILC PSGPIKSFYP LTFIQVKQYF GFVLYRTTLP KDCKDPTHLS
     SPFNGVHDRA YVSVDGVPQG VLERNIVITL NITGKAGATL DLLVENMGRV NYGNSINDFK
     GLISNLTLGS SILTDWQIFP MDTEDAVRGY LGAWHGYGGK GHHEAHTHSP SEYTLPAFYV
     ANFSIPSEIP DLPQDTFIQF PGWTKGQVWI NGFNLGRYWP ARGPQKTLFV PQHILVTSAP
     NTIIVLELEH APCGDKEPCT VEFVDKPLIG ATETWSHDAS IHRGVRLENR
//
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