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Database: UniProt
Entry: I3LHZ3_PIG
LinkDB: I3LHZ3_PIG
Original site: I3LHZ3_PIG 
ID   I3LHZ3_PIG              Unreviewed;      2734 AA.
AC   I3LHZ3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSSSCP00000023692};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSSSCP00000023692};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000023692, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000023692, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000023692};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000023692}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
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DR   EMBL; AEMK02000087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000023692; -.
DR   PaxDb; I3LHZ3; -.
DR   PRIDE; I3LHZ3; -.
DR   Ensembl; ENSSSCT00000030746; ENSSSCP00000023692; ENSSSCG00000023437.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   InParanoid; I3LHZ3; -.
DR   Reactome; R-SSC-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-SSC-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-SSC-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-SSC-418457; cGMP effects.
DR   Reactome; R-SSC-5578775; Ion homeostasis.
DR   Reactome; R-SSC-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Bgee; ENSSSCG00000023437; Expressed in 5 organ(s), highest expression level in prefrontal cortex.
DR   ExpressionAtlas; I3LHZ3; baseline and differential.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:I3LHZ3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2259   2281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2293   2311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2380   2405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2425   2447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2555   2578       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      364    420       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1578   1598       {ECO:0000256|SAM:Coils}.
FT   COILED     2672   2713       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2734 AA;  311250 MW;  3CC337D72EC6C0AF CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVDP DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL
     RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV
     SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL
     EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL
     CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
     DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF
     EFEGVSSGEN ALEAGEDEEE VWLFWRDSNK EVRSKSVREL AQDAKEGQKE DRDVLSYYRY
     QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ
     EQVTPVKYAR LWSEIPSEIA IDDYDSSGTS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS
     DKEKNKLTFE VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHVTTIFP ISKMAKGEEN
     KGSNVMRSIH GVGELMTQVV LRGGGFLPMT PTAAAPEGNV KQAEPEKEDI MVMDTKLKII
     EILQFILNVR LDYRISCLLC IFKREFDESN SQTSETSSGN SSQEGPSNVP GALDFEHIEE
     QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ
     AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDEAMDG ASGENEHKKA
     EEGNNKSQKH ESTSSYNYRV VKEILIRLSR LCVQESATVR KSRKQQQRLL RNMGAHAVVL
     ELLQIPYEKA EDTKMQEIMR LAHEFLQNFC AGNQQNQTLL HKHINLFLNP GILEAVTMQH
     IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV
     NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLMYHI HLVELLAVCT EGKNVYTEIK
     CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH MWKLFENFLV
     DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ PVFVQLLQGV
     FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD SQVNNLFLKS HNIVQKTAMN
     WRLTARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR PLVQAELSVL VDVLHRPELL
     FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL QTLREMMTKD RGYGEKLISI
     DELDNAELPQ APDSENSTEQ ELEPSPPLRQ LEDHKRGEAL RQILVNRYYG NIRPSGRRES
     LTSFGNGPLS PGGPGKPGGG GGGSGSSSMS RGEMSLAEVQ CHLDKEGASN LVIDLIMNAS
     SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF FKVFYDRMKV AQQEIKATVT
     VNTSDLGNKK KDDEVERDAP SRKKAKEPAT QITEEVRDQL LEASAATRKA FTTFRREADP
     DDHYQAGEGA QATADKTKDD LEMSAVVTIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN
     YNLVCETLQF LDCICGSTTG GLGLLGLYIN EKNVALINQT LESLTEYCQG PCHENQNCIA
     THESNGIDII TALILNDINP LGKKRMDLVL ELKNNASKLL LAIMESRHDS ENAERILYNM
     RPKELVEVIK KAYMQGEVEF EDGENGEDGA ASPRNVGHNI YILAHQLARH NKELQTMLKP
     GGQVDGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC EFLTKESKLR IYYTTERDEQ
     GSKINDFFLR SEDLFNEMNW QKKLRAQPVL YWCARNMSFW SSISFNLAVL MNLLVAFFYP
     FKGVRGGTLE PHWSGLLWTA MLISLAIVIA LPKPHGIRAL IASTILRLIF SVGLQPTLFL
     LGAFNVCNKI IFLMSFVGNC GTFTRGYRAM VLDVEFLYHL LYLLICAMGL FVHEFFYSLL
     LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS IVGYLFFKDD FILEVDRLPN
     ETALPEASES LASEFLYSDV CRVETGENCS SPAPKEELVP AEETEQDKEH TCETLLMCIV
     TVLSHGLRSG GGVGDVLRKP SKEEPLFAAR VIYDLLFFFM VIIIVLNLIF GVIIDTFADL
     RSEKQKKEEI LKTTCFICGL ERDKFDNKTV TFEEHIKEEH NMWHYLCFIV LVKVKDSTEY
     TGPESYVAEM IKERNLDWFP RMRAMSLVSS DSEGEQNELR NLQEKLESTM KLVTNLSGQL
     SELKDQMTEQ RKQKQRIGLL GHPPHMNVNP QQPA
//
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