ID I3LIP7_PIG Unreviewed; 767 AA.
AC I3LIP7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=LOC100625149 {ECO:0000313|Ensembl:ENSSSCP00000023953.3};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000023953.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000023953.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000023953.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000023953.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; I3LIP7; -.
DR STRING; 9823.ENSSSCP00000023953; -.
DR Ensembl; ENSSSCT00000026007.4; ENSSSCP00000023953.3; ENSSSCG00000024765.4.
DR GeneTree; ENSGT00940000162114; -.
DR HOGENOM; CLU_011614_4_0_1; -.
DR InParanoid; I3LIP7; -.
DR OrthoDB; 2898719at2759; -.
DR TreeFam; TF351403; -.
DR Reactome; R-SSC-445355; Smooth Muscle Contraction.
DR Proteomes; UP000008227; Chromosome 11.
DR Bgee; ENSSSCG00000024765; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0008074; C:guanylate cyclase complex, soluble; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0019934; P:cGMP-mediated signaling; IBA:GO_Central.
DR GO; GO:0070482; P:response to oxygen levels; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF17; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 493..621
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 714..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 721..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 86877 MW; 67DA91B30002B917 CRC64;
MSTGNSSETG NRESSFPQED AIARFLKAST QYGFINTCLQ SLVIEKFGEE TWEKLKARVD
VQDAFMTYTV YDDVITIKLI QEACSVLGVS MEAILKLFGE YFFKFCKMSG YDRMLRTLGG
NLTEFIENLD ALHSYLALSY QEMNAPSFRV ERAADEKMLL HYYSDRSGLC HIVPGIIEAV
AKDFFDVDVT LEILDVHQEE ERTAKKEHVV FLIVQKSHRQ MRRAKPKDSQ RDQEVQGLLS
FLRMKEKYLS VSVCPVKKSR WEVVRRIVMF GKRHLRNTFE PIYPERLWIE ERTFCNAFPF
HLVFDASLRV KQAGVNIQKY IPGLRTPKIR LDTYFSIVHP PVAFDIFSIC QFINSPFVLK
ARGERLPEAG RSRPPLKLRG QMIWMESTRC MVYLCSPKLR SLRELEERQM HLSDIAPHDT
TRDLILLNQQ RLAEMELSNQ LERKKEELRV LSKHLAIEKK KTEALLYAML PKHVANQLKE
GRKVAAGEFK TCTILFSDVV TFTTICAACE PIQIVNMLNS MYSKFDRLTS VHDVYKVETI
GDAYMVVGGV PVPIGSHAQR VANFALGMRL SAKEVMNPVT GEPIQIRVGI HTGPVLAGVV
GDKMPRYCLF GDTVNTASRM ESHGLPNKVH LSPTAYRALE NQGFEITERG EIEVKGKGKM
TTYFLIRNVN ASEDELMGRP RTPLHPEEAS APGNQDRTLA VMRYADSCQR LPEGDAARAS
DQSTPRESPA ASGQDSVEAA NGQRSSDETK TQRLPGEPLP SGFCALL
//