ID I3LJW2_PIG Unreviewed; 446 AA.
AC I3LJW2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Fibrinogen gamma chain {ECO:0000313|Ensembl:ENSSSCP00000024374.3};
GN Name=FGG {ECO:0000313|Ensembl:ENSSSCP00000024374.3,
GN ECO:0000313|VGNC:VGNC:88122};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000024374.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000024374.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024374.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000024374.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_005666850.1; XM_005666793.1.
DR AlphaFoldDB; I3LJW2; -.
DR STRING; 9823.ENSSSCP00000024374; -.
DR Ensembl; ENSSSCT00000026223.4; ENSSSCP00000024374.3; ENSSSCG00000024314.4.
DR GeneID; 403164; -.
DR CTD; 2266; -.
DR VGNC; VGNC:88122; FGG.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000158467; -.
DR InParanoid; I3LJW2; -.
DR TreeFam; TF336658; -.
DR Reactome; R-SSC-114608; Platelet degranulation.
DR Reactome; R-SSC-140875; Common Pathway of Fibrin Clot Formation.
DR Reactome; R-SSC-216083; Integrin cell surface interactions.
DR Reactome; R-SSC-354192; Integrin signaling.
DR Reactome; R-SSC-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins.
DR Reactome; R-SSC-372708; p130Cas linkage to MAPK signaling for integrins.
DR Reactome; R-SSC-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-SSC-5674135; MAP2K and MAPK activation.
DR Reactome; R-SSC-5686938; Regulation of TLR by endogenous ligand.
DR Reactome; R-SSC-8957275; Post-translational protein phosphorylation.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000024314; Expressed in liver and 24 other cell types or tissues.
DR ExpressionAtlas; I3LJW2; baseline.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0070527; P:platelet aggregation; IBA:GO_Central.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 1.20.5.50; -; 2.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 4.10.530.10; Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF4; FIBRINOGEN GAMMA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 1: Evidence at protein level;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LJW2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..446
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036453892"
FT DOMAIN 171..417
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT COILED 60..161
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 446 AA; 50753 MW; 4B09B5BA69C8FA3E CRC64;
MTWSSHPRSL IILSFYTLSM LSSTCLAYVA TRENCCILDE RFGSYCPTMC GIAGFLSTYQ
NTVEKDLQNL EGILHQVENK TSEARELIKA IQISYNPEDL SKPDRIQSAT KESKKMLEEI
MKYENLITTH DSTIRFLQEI YNSNNQKISN LKQKVIQLEA KCQEPCKDTV KIHDTTGKDC
QEIANKGARE SGLYFIKPLK APKKFLVYCE IDGSGNGWTV FQKRVDGSED FKKNWIQYKE
GFGHLSPTGT TEFWLGNEKI HLITTQSAIP YVLRVQLEDW SGKTSTADYS TFRVGPESDK
YRMTYAYFLG GDAGDAFDGF DFGDDSSDKF LTSHNGMQFS TWDNDNDKFD GNCAEQDGSG
WWMNKCHAGH LNGVYYPGGT YSKSSTPNGY DNGIIWATWK SRWYSMKKTT MKLIPYNRIA
IEDGQQHSLG GAKQVRPDHH VEIEYD
//
