ID I3LK01_PIG Unreviewed; 407 AA.
AC I3LK01;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN Name=LOC100621639 {ECO:0000313|Ensembl:ENSSSCP00000024415.3};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000024415.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000024415.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024415.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000024415.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; I3LK01; -.
DR SMR; I3LK01; -.
DR STRING; 9823.ENSSSCP00000024415; -.
DR PaxDb; 9823-ENSSSCP00000024415; -.
DR PeptideAtlas; I3LK01; -.
DR Ensembl; ENSSSCT00000031278.4; ENSSSCP00000024415.3; ENSSSCG00000020838.4.
DR eggNOG; ENOG502TD7W; Eukaryota.
DR GeneTree; ENSGT00940000154026; -.
DR HOGENOM; CLU_012560_5_0_1; -.
DR InParanoid; I3LK01; -.
DR TreeFam; TF317854; -.
DR Reactome; R-SSC-6805567; Keratinization.
DR Reactome; R-SSC-6809371; Formation of the cornified envelope.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000020838; Expressed in lung.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF51; IF ROD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 95..406
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 113..224
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 297..384
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 407 AA; 46040 MW; F9E0EAEE88238B94 CRC64;
FSCTSASGPR PGRCCITAAP YRGVSCYRGL TGGFGSRSVS GGFGAGSSGR SFGYRSGGVV
RPSPPCITTV SINESLLAPL NLEIDHNAQS VKQEEKEQIK ILNSRFAAFI DKVRFLEQQN
KLLETKLQFF QNRKCCESNL EPLFNGYIET LRREAERVEA DRGRLASELN HVHEVLEGYK
KKYEEEVALR TTAENEFVRI KQEVNSLSVQ KADLKANAQS LAEEVGFLKT LYEEEIRVLQ
AHISDTLVIV KMDNSRDLNM DSIIAEIKAH YDDIASRSRA EAESWYRTKY EEIKATVVQH
GETLRRTKEE INELNRVIQR LTAEIENAKR QNSKLEAAVS QAEQQGQAAL NDARYKLTEL
EAALQKAKQD MAFLLKEYQE VMSSKLALDI EIATYRRLLE GEEQRWV
//
