ID I3LKC4_PIG Unreviewed; 647 AA.
AC I3LKC4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Mex-3 RNA binding family member D {ECO:0000313|Ensembl:ENSSSCP00000024538.3};
GN Name=MEX3D {ECO:0000313|Ensembl:ENSSSCP00000024538.3,
GN ECO:0000313|VGNC:VGNC:90171};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000024538.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000024538.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024538.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000024538.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; I3LKC4; -.
DR STRING; 9823.ENSSSCP00000024538; -.
DR PaxDb; 9823-ENSSSCP00000024538; -.
DR Ensembl; ENSSSCT00000022668.3; ENSSSCP00000024538.3; ENSSSCG00000021750.4.
DR VGNC; VGNC:90171; MEX3D.
DR eggNOG; KOG2113; Eukaryota.
DR GeneTree; ENSGT00940000162613; -.
DR HOGENOM; CLU_025598_2_1_1; -.
DR InParanoid; I3LKC4; -.
DR OrthoDB; 50983at2759; -.
DR TreeFam; TF315107; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000021750; Expressed in testis and 45 other cell types or tissues.
DR ExpressionAtlas; I3LKC4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IEA:Ensembl.
DR CDD; cd22423; KH-I_MEX3_rpt1; 1.
DR CDD; cd22424; KH-I_MEX3_rpt2; 1.
DR CDD; cd16518; RING-HC_MEX3; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047228; KH-I_MEX3_rpt1.
DR InterPro; IPR047226; KH-I_MEX3_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047227; MEX3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23285; RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23285:SF3; RNA-BINDING PROTEIN MEX3D; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 596..636
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..51
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 64567 MW; EAECF9637B4A6FE2 CRC64;
MPSSTGQPDG GGGARGGGPG AAVGADPPGP PPPPEGAEEA APAPRPPPEP DDAAAALRLA
LDQLSELGLG GAGDQDEEGA AAGGGDGAAA AGGGTDGGTE AEPAPPDGPE TGAPGVAVAP
GPLPLLEPDV SPRPSPPDVF AGFAPHPAAL GPPTLLAEQM SVIGSRKKSV NMTECVPVPS
SEHVAEIVGR QGCKIKALRA KTNTYIKTPV RGEEPVFIVT GRKEDVEMAK REILSAAEHF
SVIRATRSKA GGLPGATQGP PNLPGQTTIQ VRVPYRVVGL VVGPKGATIK RIQQRTHTYI
VTPGRDKEPV FAVTGMPENV DRAREEIEAH ITLRTGAFTD AGPDSDFHSN GTDVCLDLLG
AAAGLWAKAP NPGRRPPAPT ASLRGDAALG APGGPEAFYA GSRGGPPVPV PVPDAGPASP
YGASGNGGFT FGGDGTGAAA GPPAPEDCDF GFDFLALDLT VPAAATIWAP FDRAAPLPAF
SGCSAVNGAP TTPGPGARRS SGAGTPRHSP TLPEPGGLGL ELPLARRPAP DPVGALPWRP
PQGSLASFSS GSSFSTATSL PSGSSASPLD SGATESSRKP LAAPPPAPTP ALARECVVCA
EGEVMAALVP CGHNLFCMDC AVRICGKSEP ECPACRTPAT QAIHIFS
//
