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Database: UniProt
Entry: I3LLB1_PIG
LinkDB: I3LLB1_PIG
Original site: I3LLB1_PIG 
ID   I3LLB1_PIG              Unreviewed;      1951 AA.
AC   I3LLB1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 48.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSSSCP00000024878};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000024878, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000024878, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024878};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000024878}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AEMK02000085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000024878; -.
DR   PaxDb; I3LLB1; -.
DR   PRIDE; I3LLB1; -.
DR   Ensembl; ENSSSCT00000023726; ENSSSCP00000024878; ENSSSCG00000011260.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3LLB1; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Reactome; R-SSC-5576892; Phase 0 - rapid depolarisation.
DR   Proteomes; UP000008227; Chromosome 13.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    373    401       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    656    682       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    694    716       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    783    803       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    866    889       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1150   1168       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1189   1211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1217   1236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1281   1301       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1354   1374       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1394   1415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1541   1572       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1621       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1693   1719       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    407       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      665    894       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      903   1144       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1148   1423       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1473   1729       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      998   1018       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1951 AA;  220496 MW;  2B985A36C06262F5 CRC64;
     MEFPFGILET TNFRRFTPES LVEIEKRIAA KQAVKKTKEK PRVQKGQKEK ARPQLDLKAC
     NQLPKFYGEL PAELVGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS YPLWFSLFIT ITILVNCVGM TQSELPERIE YVFTVIYTFE ALIKILARGF
     CLNEFTYLRD PWNWLDFSVI TLAYVGEAID LRGISGLRTF RVLRALKTVS VIPGLKVIVG
     ALIHSVRKLA DVTILTIFCL SVFALVGLQL FKGNLKNKCV KNCTLVNETA NYSSHEKQEW
     NFCPGGCTVD NILCFCCSHC PEGYFCLKTS DNPDFNYTSF DSFAWAFLSL FRLMTQDSWE
     RLYQQTLRAS GKFYMVFFVL VIFLGSFYLV NLILAVVTMA YEEQNKATIA EIEAKEKMYQ
     ETFEMCQKEQ KVLEALGVDT ASLCSHNGSS LASKTASERR YRMKPRVSEG STDDKSPQSE
     PYNQHRMSFL GLTSGRRRAS HGSVFHFQAP GRDISFPDGV TDDGIFPGDH ESRRGSLLLG
     RGAGQQSPLA RSPLPQTLNP GSGRGEDGHP TLPTGELAPG ANEVSALDAG QKTFLTAEYL
     NETFRVQRAM SVVSIMTSVL EELEESKPRC PRCLTNWAQK YLIWKCCPTW VKLKKLLWSI
     VTDPFAELTI TLCIVVNTIF MAMEHHGMSP TFEAMLQIGN IVFTVFFTAE MVFKIIAFDP
     YYYFQNRWNI FDCIIVTVSL IELGMARKGS LTVLRTFRLL RVFKLAKSWP TLNMLIKIIG
     NSVGALGNLT IILAIIVFVF ALVGKQLLGE SYNTNRHKIS APKEDWPRWH MHDFFHSFLI
     VFRILCGEWI ENMWACMEVG QKSICLILFL TVMVLGNLVV LNLFIALLLN SFSADNLTTQ
     EDDGEVNNLQ LALARIQLFG QRTKEALCSF LNQPCLLPQP KAEPQLVVKL PLSTPKAKNH
     IAADTAVVKP GGLPAPRGPR DDHSDFITNP NIWVSVPIAE GESDLDDLED DAEEDARSTQ
     QEVIPQGQEQ LQQVGRSEDS SSRSPGPGTS SEDLAPYLGE KWKAKAAAQG PAEGMDDTSS
     SEGSTVDCLD PEEILRKIPE LADDLDEPDD CFTEGCIRHC PCCRVNSSKL PWAVSWQVRK
     TCHRIVEHSW FESFIIFMIL LSSGALAFED FYLDQKPTVK ALLEYTDRVF TFIFVFEMLL
     KWVAYGLNSY FTNAWCWLDF LIVNISLTSL IAKLLQYSDM ASIKALRTLR ALRPLRALSR
     FEGMRVVVDA LVGAIPSIMN VLLVCLIFWL IFSIMGVNFF AGKFQKCINN TTEGFLLVPW
     TTVNNISDCE RQNYTGSLFW VNVKVNFDNV AMGYLALLQV ATFKGWMDIM YAAVDSREVN
     MQPKWEDNVY MYMYFVIFII FGGFFTLNLF VGVIIDNFNQ QKKKIRGQDI FMTEEQKKYY
     NAMKKLGSKK PQKPIPRPLN KYQGFVFDIV TKKTFDIIIM VLICLNMITM MVETDEQSEE
     KTKILNKINQ FFVAVFTGEC VTKMFALRHY YFINGWNVFD FIVVVLSVLS LVFAEILTSL
     GVFFSPTLLR VIRLARIGRI LRLIRGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYSI
     FGMANFAYVK WEAGIDDMFN FQTFANSMLC LFQITTSAGW DGLLSPILNT GPPYCDPHLP
     NSSSTRGDCG NPLVGILFFT TYIIISFLIV VNMYIAVILE NFNVATEEST EPLSEDDFDM
     FYETWEKFDP EATQFITFSA LSDFADTLTG PLRIPKPNRN ILIQMDLPLV PGDKIHCLDI
     LFAFTKNVLG ESGELDSLKA NMEEKFMATN LSKASYEPIA TTLRWKQEDI SATVIQKAYR
     SYVLQRSMTI SSPSGVPRAE EEAVPVPDEG FVTFMANENH MLPDKSETAS ATSFPPSYDS
     VTRGLSDQVN LSTSSSMQHE NEAANKEAPG P
//
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