ID I3LLH3_PIG Unreviewed; 603 AA.
AC I3LLH3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Zinc finger protein 276 {ECO:0000313|EMBL:HDB73353.1, ECO:0000313|Ensembl:ENSSSCP00000024942.2};
GN Name=ZNF276 {ECO:0000313|Ensembl:ENSSSCP00000024942.2,
GN ECO:0000313|VGNC:VGNC:95214};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000024942.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000024942.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000024942.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB73353.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000024942.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01217876; HDB73353.1; -; Transcribed_RNA.
DR EMBL; DQIR01255705; HDC11183.1; -; Transcribed_RNA.
DR RefSeq; XP_003355762.1; XM_003355714.3.
DR STRING; 9823.ENSSSCP00000024942; -.
DR PaxDb; 9823-ENSSSCP00000024942; -.
DR Ensembl; ENSSSCT00000022755.4; ENSSSCP00000024942.2; ENSSSCG00000029228.4.
DR GeneID; 100628034; -.
DR KEGG; ssc:100628034; -.
DR CTD; 92822; -.
DR VGNC; VGNC:95214; ZNF276.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158841; -.
DR HOGENOM; CLU_040755_0_0_1; -.
DR OrthoDB; 5315505at2759; -.
DR TreeFam; TF332664; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000029228; Expressed in blood and 44 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24406; TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED; 1.
DR PANTHER; PTHR24406:SF3; ZINC FINGER PROTEIN 276; 1.
DR Pfam; PF07776; zf-AD; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS51915; ZAD; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 78..164
FT /note="ZAD"
FT /evidence="ECO:0000259|PROSITE:PS51915"
FT DOMAIN 462..492
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 493..520
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 521..548
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 551..579
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..329
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 80
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 83
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 140
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
SQ SEQUENCE 603 AA; 65170 MW; 0C1AF1CE4F8325B6 CRC64;
MKRDRLGRFL SSGQRGSTGG SSYGGGRARG RPARSGPTVA EAAALVAARL SWGPARACAD
AGEDGADEAG TARALAMGHC RLCHGKFSSR SLRSISGRAP GESSERPPPG ERVFVRDFQR
LLGVAVLQDP ALSQFVCKNC LAQFYQCHGL LTCFLQRVNV SPTGHRKPGA KVGVQPLPGE
EGACVVDLIT SSAQGLRGLV GWVHGHAASC GALPSLQSTL PSEYCGVVQA VWGCGQGHGY
TMDAGSRCGA LLLDGALGVK WTWDKEKAPW LSQHRGASPT GAAPQSSQGR VTAAGTEMPP
TTDTARPPSD GDPVGPGPGP PPEPSLPPSG APGHLGEKQV PSPTSDDRVK DEFSDLSEGG
FLSEDDDDRK QNTHSSDESF EPLPEKRGSG RKTESREAKK LDEPKLRKKP GPKPGWKSKP
RCEREELPTI YKCPHQGCTA VYRGADGMKK HVKEHHEEVR ERPCPHPGCN KVFMIDRYLQ
RHVKLIHTEV RNYICDECGQ TFKQRKHLLV HQMRHSGAKP LQCEVCGFQC RQRASLKYHM
TKHKAETELD FACDQCGRRF EKAHNLNVHM SMVHPLTQSQ DKAAALEPLP GAEGRPAVKP
EPT
//
