ID I3LMJ9_PIG Unreviewed; 998 AA.
AC I3LMJ9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN Name=SUPT5H {ECO:0000313|Ensembl:ENSSSCP00000025320.3,
GN ECO:0000313|VGNC:VGNC:93625};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000025320.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000025320.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000025320.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000025320.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR AlphaFoldDB; I3LMJ9; -.
DR Ensembl; ENSSSCT00000030229.4; ENSSSCP00000025320.3; ENSSSCG00000023556.4.
DR VGNC; VGNC:93625; SUPT5H.
DR GeneTree; ENSGT00440000037640; -.
DR TreeFam; TF105730; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000023556; Expressed in oocyte and 43 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR PIRSF; PIRSF036945; Spt5; 3.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 5.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 1: Evidence at protein level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LMJ9};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 135..226
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 231..258
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 365..392
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 417..444
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 539..566
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 680..816
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 945..972
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..48
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 111402 MW; DE3ACE9F86362280 CRC64;
VQNPGAPTLQ VEEERRSAAG SEKEEEPEEE EEEEEEEEYD EEEEEEDDDR PPKKPRHGGF
ILDEAASNID NVVLDEDRSG ARRLQNLWRD QREEELGEYY MKKYAKSSVG ETVYGGSDEL
SDDITQQQLL PGVKDPNLWT VKCKIGEERA TAISLMRKFI AYQFTDTPLQ IKSVVAPEHV
KGYIYVEAYK QTHVKQAIEG VGNLRLGYWN QQMVPIKEMT DVLKVVKEVA NLKPKSWVRL
KRGIYKDDIA QVDYVEPSQN TISLKMIPRI DYDRIKARMS LKDWFAKRKK FKRPPQRLFD
AEKIRSLGGD VASDGDFLIF EGNRYSRKGF LFKSFAMSAV ITEGVKPTLS ELEKFEDQPE
EREHNFQPGD NVEVCEGELI NLQGKILSVD GNKITIMPKH EDLKDMLEFP AQELRKYFKM
GDHVKVIAGR FEGDTGLIVR VEENFVILFS DLTMHELKVL PRDLQLCSET ASGVDVGGQH
EWGELVQLDP QTVGVIVRLE RETFQVLNMY GKVVTVRHQA VTRKKDNRFA VALDSEQNNI
HVKDIVKVID GPHSGREGEI RHLFRSFAFL HCKKLVENGG MFVCKTRHLV LAGGSKPRDV
TNFTVGGFAP MSPRISSPMH PSRGQGFGSP GGGGGGMSRG RGRRDNELIG QTVRISQGLH
WGSRRPGGMT STYGRTPMYG SQTPMYGSGS RTPMYGSQTP LQDGSRTPHY GSQTPLHDGS
RTPAQSGAWD PNNPNTPSRA EEEYEYAFDD EPTPSPQAYG GTPNPQTPGY PDPSSPQVNP
QYNPQTPGTP AMYNTDQFSP YAAPSPQGSY QPSPSPQSYH QVAPSPQATR TPIHQPAITP
HPRPWPIRYW SASPSPSPVG YSPMTPGAPS PGGYNPHTPG SGIEQNSSDW VTTDIQVKVR
DTYLDTQVVG QTGVIRSVTG GMCSVYLKDS EKVVSISSEH LEPITPTKNN KVKVILGEDR
EATGVLLSID GEDGIVRMDL DEQLKILNLR FLGKLLEA
//
