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Database: UniProt
Entry: I3LPL6_PIG
LinkDB: I3LPL6_PIG
Original site: I3LPL6_PIG 
ID   I3LPL6_PIG              Unreviewed;      1748 AA.
AC   I3LPL6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSSSCP00000026043};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000026043, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000026043, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000026043};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000026043}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AEMK02000085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; I3LPL6; -.
DR   Ensembl; ENSSSCT00000023912; ENSSSCP00000026043; ENSSSCG00000029419.
DR   GeneTree; ENSGT00830000128242; -.
DR   Reactome; R-SSC-5576892; Phase 0 - rapid depolarisation.
DR   Proteomes; UP000008227; Chromosome 13.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF210; PTHR10037:SF210; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    157    176       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    188    205       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    240    260       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    344    363       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    549    567       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    579    600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    670    693       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    752    777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1024   1042       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1063   1082       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1088   1107       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1133   1166       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1253   1277       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1327   1350       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1370   1388       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1400   1418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1455   1483       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1503   1526       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1547   1573       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    380       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      549    786       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      793   1018       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1022   1285       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1334   1583       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      381    405       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1748 AA;  200564 MW;  23CA5875EC4F8D69 CRC64;
     MDDRCYPVIF PDARNFCPFT PDSLAAIEKQ IAIQKEKKNS KDQTAPEPQH RPQLDLKVSR
     KLPKLYGDIP PELIAKPLED LDPFYRNHKT FMVLNKNRTI YRFSAKRALF IFGPFNSIRS
     LAIRISTRVT LFSMFIICTV VINCVFMATA HGKKSIFVLH ASVLSLIKIL ARGFILDEFS
     FLRDPWNWLD SIVIATVSSI SLSSLRTFRV FRALKAISVV SGLKVIVGAL LRSVKKLVDV
     MILTLFCLSI FALVGQQLFM GSLDQKCVSK DCDSDNKVCN SPSFPLFPIS RACSEQFECN
     HTRWNPDYNY TNFDNFGWSF LAMFRLMTQD SWEKLYRQTL RTSGLYSVFF FVLVIFLGSF
     YLINLTLAVV TMAYEEQNKN VAAETEAKEK MFQEAQQLLK EEKEALVAMG IDRSSLNSLE
     ASSFSPKKRR LFGNKKRKSF FLRESGKDQV PGSDSDEDSS KKPHLLEQTK RLSQNLSVDY
     SDEHGDPLQR QRALSAVSIL TITMHEQEKS QEPCLPCGEN LASKYLVWDC NPQWLCIKKA
     LRLVMTDPFT ELAITICIII NTIFLAMEHY QMDTSFETML CTGNLVFAGI FMAEMCLKII
     ALDPYHYFRR GWNIFDSIVA LLSFADVMLN TEKKSWKLFR SLRVLRVFKL AKSWPTLNTL
     IKIIGHSVGA LGNLTVVLAI VVFIFSVVGM QLFGSRFNST RTNSKSRDCA NSCLRRWHME
     DFYHSFLVVF RILCGEWIEN MWECMQEANQ PLCIIVFLSI MVIGKLVVLN LFIALLLNSF
     SNEERDGQLE GEGRKTKVHL ALDRFRRAFC FVLYTLEHFW RKWRKKQHLP KQKEMTERPA
     TEGKDVIPLV TKIKKGPETW EEFCALSSAP RTSSVGNDWT WLAPLAEEED DVESLCEHMA
     HPVRQPEAGQ QACELHHKNK ESNSPGVQSV EIDIFSEDVP YLSIQNSRKK SDAATSVLSE
     CSTIDPQDPF RHIPEMVPKK EPERCLPRGL GCCFPCCALD KRKSPWIIWW KLRKTCYQIV
     NHSWFESFII FVILLSSGAL VFEDIHLEKQ PQIQTLLNCT DHIFTYIFVL EMGLKWVAFG
     FQKYFTSAWC WLDFVIVIVS VTSLIDVKGL KSFRTLRALR PLRALSQFEG MKVVVYALIG
     AIPAILNVLL VCLIFWLIFC ILGVHFFSGK FGRCVNVTDE NAVINDSLVT NRNQCESENL
     SWMPQSVNFD NVGMAYLALL QVATFKGWMD IMYAAVDSRE EGKQPRFEEN PYVYLYFVVF
     IIFGSFFTLN LFIGVIIDNF NQQQKKISGQ DIFMTEEQKK YYNAMKKLGS KKPQRPIPRP
     LNKCQGLVFD LVTHQVFDII IIILIFLNMV SMMAESHDQS DRMKLILERL NLAFVVIFTM
     ECLIKIFALR QYYFTNGWNL FDCVIVILSI VSTMVSVLED QEHIPFPPTL FRVVRLARIG
     RILRLVRAAR GIRTLLFALM MSLPSLFNIG LLLFLIMFIY AIFGMNSFCK VKQGSGIDDI
     FNFETFVGSM LCLFQITTSA GWDALLNPML QSKDSCNRTS ENCHLSAIAT TYFVSYIIIS
     FLIVVNMYIA VILENFNTAT EESEDPLGED DFEMFYEVWE KFDPEATQFI KYSALSDFAD
     ALPEPLRVAK PNKYQFLVMD LPMVSGDRLH CLDILFAFTA RVLGESSGLD SIKAMMEEKF
     MEANPFKKLY EPIKEEERCA AVIQKAFRKY MTKMTKCTLE DRPHSPLQTL CNGDLSNSGM
     AEGKVHYD
//
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