ID I3LS87_PIG Unreviewed; 677 AA.
AC I3LS87;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Vasorin {ECO:0000313|EMBL:HDA40051.1, ECO:0000313|EMBL:HDB53188.1, ECO:0000313|Ensembl:ENSSSCP00000026980.1};
GN Name=VASN {ECO:0000313|Ensembl:ENSSSCP00000026980.1,
GN ECO:0000313|VGNC:VGNC:94803};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000026980.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000026980.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000026980.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA40051.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000026980.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DQIR01084575; HDA40051.1; -; Transcribed_RNA.
DR EMBL; DQIR01084576; HDA40052.1; -; Transcribed_RNA.
DR EMBL; DQIR01087844; HDA43320.1; -; Transcribed_RNA.
DR EMBL; DQIR01197711; HDB53188.1; -; Transcribed_RNA.
DR EMBL; DQIR01312718; HDC68196.1; -; Transcribed_RNA.
DR RefSeq; XP_005662230.1; XM_005662173.2.
DR RefSeq; XP_005662231.1; XM_005662174.2.
DR RefSeq; XP_013851147.1; XM_013995693.1.
DR STRING; 9823.ENSSSCP00000051056; -.
DR PaxDb; 9823-ENSSSCP00000026980; -.
DR Ensembl; ENSSSCT00000027262.4; ENSSSCP00000026980.1; ENSSSCG00000025561.4.
DR Ensembl; ENSSSCT00000047975.3; ENSSSCP00000051056.1; ENSSSCG00000025561.4.
DR GeneID; 102158247; -.
DR KEGG; ssc:102158247; -.
DR CTD; 114990; -.
DR VGNC; VGNC:94803; VASN.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159318; -.
DR HOGENOM; CLU_432517_0_0_1; -.
DR OMA; GPWVRES; -.
DR OrthoDB; 5353685at2759; -.
DR TreeFam; TF351825; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000025561; Expressed in forelimb bud and 35 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050431; F:transforming growth factor beta binding; IBA:GO_Central.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0071461; P:cellular response to redox state; IEA:Ensembl.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF160; VASORIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51450; LRR; 2.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LS87};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..677
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014579593"
FT TRANSMEM 581..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..446
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 466..562
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 359..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..383
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..409
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 436..445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 677 AA; 72187 MW; D6085B931D98DB3C CRC64;
MPPTISPPLL LPLLLLLLLA LEPRVQGCPS GCQCNQPQTV FCTARQGTTV PLDVPPDTVG
LYIFENGITT IDTGSFAGLP GLQLLDLSQN QITSLPGGVF QPLANLSNLD LTANRLREIT
NETFRGLRRL ERLYLGKNRI RHIQPGAFDA LEHLLELKLQ DNELRALPPL RLPRLLLLDL
SHNSLPALEP GVLDTANVEA LRLAGLGLQQ LDEGLLGRLR NLHDLDVADN QLERVPPAIR
GLRGLTRLRL AGNTRIAQLR PEDLAGLAAL QELDLSNLSL QVLPHELSIL FPRLRLLAAA
RNPFNCVCPL SWFGPWVRES RVALTSPEET RCHFPPKNAG RLLLDLDYAD FGCPATTTTA
TVPATRPTVG EPTFPPSSPA PTWLSPTEPA TVAPSLPPPA PPTEGPAPQP QDCPASICLN
GGTCHLEARG HLECLCPEGF TGLYCESRVR QGPRPSSAPA TLQPPRPLPL SIEPVSPTSL
RVGLQRYLQG SPLQLRSLRL TYRNLSGPDK RPVTLRLPAS LAEYTVTQLR PNATYSICVR
PLGAGRMPEG EEACGEARTP PAVRSNHAPV TQAREGNLPL LIAPTLAAVL LAVLAAVGAA
FCVRRGRAAA AVAQGKGQVG PGAGPLELEG VKAPLEPGPK GTEGGGEAPP GGPECEVPLM
GYSGPGPQGP LPTKPYI
//
