ID I3LUT7_PIG Unreviewed; 537 AA.
AC I3LUT7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=KPNA5 {ECO:0000313|Ensembl:ENSSSCP00000027888.3,
GN ECO:0000313|VGNC:VGNC:89564};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000027888.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000027888.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000027888.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000027888.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in nuclear protein import.
CC {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR AlphaFoldDB; I3LUT7; -.
DR PaxDb; 9823-ENSSSCP00000004603; -.
DR Ensembl; ENSSSCT00000024609.4; ENSSSCP00000027888.3; ENSSSCG00000004262.5.
DR VGNC; VGNC:89564; KPNA5.
DR eggNOG; KOG0166; Eukaryota.
DR GeneTree; ENSGT01050000244950; -.
DR HOGENOM; CLU_018084_4_1_1; -.
DR OrthoDB; 916229at2759; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000004262; Expressed in metanephros cortex and 44 other cell types or tissues.
DR ExpressionAtlas; I3LUT7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF10; IMPORTIN SUBUNIT ALPHA-6; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..63
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 168..201
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 210..238
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 537 AA; 60366 MW; 7BB12F0351DE9C6B CRC64;
LLNHYAMASP GKDNYRMKSY KNKALNPQEM RRRREEEGIQ LRKQKREEQL FKRRNVSLPK
SDESMLESPI QDPDITSTEE VITTDMVQMI FSNNADQQLT ATQKFRKLLS KEPNPPIDQV
IQKPGVVQRF VKFLERNENC TLQFEAAWAL TNIASGTFLH TKVVIETGAV PIFIKLLNSE
HEDVQEQAVW ALGNIAGDNA ECRDFVLNCE ILPPLLELLT NSDRLTTTRN AVWALSNLCR
GKNPPPNFSK VSPCLNVLSR LLFSSDPDVL ADVCWALSYL SDGPNDKIQA VIDSGVCRRL
VELLMHSDYK VVSPALRAVG NIVTGNDIQT QVILNCSALP CLLHLLSSSK ESIRKEACWT
VSNITAGNRA QIQAVIDANI FPVLIEILQK AEFRTRKEAA WAITNATSGG TPEQIRYLVA
LGCIKPLCDL LTVMDSKIVQ VALNGLENIL RLGEQESKQN GIGVNPYCAL IEEAYGLDKI
EFLQSHENQE IYQKAFDLIE HYFGVEDDDP SIVPQVDENQ QQFVFQQQEA PMEGFHL
//
