ID I3LVF2_PIG Unreviewed; 1451 AA.
AC I3LVF2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSSSCP00000028104.3};
GN Name=PTCH1 {ECO:0000313|Ensembl:ENSSSCP00000028104.3,
GN ECO:0000313|VGNC:VGNC:96513};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028104.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000028104.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028104.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000028104.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9823.ENSSSCP00000028104; -.
DR PaxDb; 9823-ENSSSCP00000028104; -.
DR PeptideAtlas; I3LVF2; -.
DR Ensembl; ENSSSCT00000029331.4; ENSSSCP00000028104.3; ENSSSCG00000027312.4.
DR VGNC; VGNC:96513; PTCH1.
DR eggNOG; KOG1935; Eukaryota.
DR GeneTree; ENSGT00940000159011; -.
DR HOGENOM; CLU_002506_1_0_1; -.
DR InParanoid; I3LVF2; -.
DR OrthoDB; 1219406at2759; -.
DR TreeFam; TF106489; -.
DR Reactome; R-SSC-5610787; Hedgehog 'off' state.
DR Reactome; R-SSC-5632681; Ligand-receptor interactions.
DR Reactome; R-SSC-5632684; Hedgehog 'on' state.
DR Proteomes; UP000008227; Chromosome 10.
DR Bgee; ENSSSCG00000027312; Expressed in forelimb bud and 44 other cell types or tissues.
DR ExpressionAtlas; I3LVF2; baseline and differential.
DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0030332; F:cyclin binding; IEA:Ensembl.
DR GO; GO:0097108; F:hedgehog family protein binding; IBA:GO_Central.
DR GO; GO:0008158; F:hedgehog receptor activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0005113; F:patched binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0005119; F:smoothened binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0061005; P:cell differentiation involved in kidney development; IEA:Ensembl.
DR GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
DR GO; GO:0072203; P:cell proliferation involved in metanephros development; IEA:Ensembl.
DR GO; GO:0071397; P:cellular response to cholesterol; IEA:Ensembl.
DR GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0009957; P:epidermal cell fate specification; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0003007; P:heart morphogenesis; IEA:Ensembl.
DR GO; GO:0035137; P:hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0060603; P:mammary gland duct morphogenesis; IEA:Ensembl.
DR GO; GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0072205; P:metanephric collecting duct development; IEA:Ensembl.
DR GO; GO:0051782; P:negative regulation of cell division; IEA:Ensembl.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0040015; P:negative regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IBA:GO_Central.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0021997; P:neural plate axis specification; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045606; P:positive regulation of epidermal cell differentiation; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR GO; GO:0010157; P:response to chlorate; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
DR GO; GO:0061053; P:somite development; IEA:Ensembl.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 440..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1028..1049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1055..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1084..1110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1122..1142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1154..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1303..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1451 AA; 160624 MW; B8E419F13593D75C CRC64;
MASAGNAAEP QDLGSGGSGG SCSGAPGRPA GGGRRRRTGG LRRNAAPDRD YLHRPSYCDA
AFALEQISKG KATGRKAPLW LRAKFQRLLF KLGCYIQKNC GKFLVVGLLI FGAFAVGLKA
ANLETNVEEL WVEVGGRVSR ELNYTRQKIG EEAMFNPQLM IQTPKEEGAN VLTTEALRQH
LDSALQASRV HVYMYKQWKL EHLCYKSGEL ITETGYMDQI IEYLYPCLII TPLDCFWEGA
KLQSGTAYLL GKPPLQWTNF DPLEFLEELK KINYQVDSWE EMLNKAEVGH GYMDRPCLNP
ADPDCPATAP NKNTTKPLDM ALVLNGGCHG LSRKYMHWQE ELIVGGTVKN STGKLVSAHA
LQTMFQLMTP KQMYEHFKGY EYVSHISWNE DKAAAILEAW QRTYVEVVHQ SVAQNSTQKV
LSFTTTTLDD ILKSFSDVSV IRVASGYLLM LAYACLTMLR WDCSKSQGAV GLAGVLLVAL
SVAAGLGLCS LIGISFNAAT TQVLPFLALG VGVDDVFLLA HAFSETGQNK RIPFEDRTGE
CLKRTGASVA LTSISNVTAF FMAALIPIPA LRAFSLQAAV VVVFNFAMVL LIFPAILSMD
LYRREDRRLD IFCCFTSPCV SRVIQVEPQA YTETHDNTRY SPPPPYSSHS FAHETQITMQ
STVQLRTEYD PHTHVYYTTA EPRSEISVQP VTLAQDTLSC QSPESTSSTR DLLSQFSDSS
LHCLEPPCTK WTLSSFAEKH YAPFLLKPKA KVVVIFLFLG LLGVSLYGTT RVRDGLDLTD
IVPRETREYD FIAAQFKYFS FYNMYIVTQK ADYPNIQHLL YDLHKSFSNV KYVMLEENKQ
LPKMWLHYFR DWLQGLQDAF DSDWETGKIM PNNYKNGSDD GVLAYKLLVQ TGSRDKPIDI
SQLTKRRLVD ADGIINPSAF YIYLTAWVSN DPVAYAASQA NIRPHRPEWV HDKADYMPET
RLRIPAAEPI EYAQFPFYLN GLRDTSDFVE AIEKVRTICN NYTSLGLSSY PNGYPFLFWE
QYIGLRHWLL LSISVVLACT FLVCAVFLLN PWTAGIIVTV LALMTVELFG MMGLIGIKLS
AVPVVILIAS VGIGVEFTVH VALAFLTAIG DKNRRAVLAL EHMFAPVLDG AVSTLLGVLM
LAGSEFDFIV RYFFAVLAIL TILGVLNGLV LLPVLLSFFG PYPEVSPANG LNRLPTPSPE
PPPSVVRFAV PPSHANNGSD SSDSEYSSQT TVSGISEELR AYEAQQGTGG PAHQVIVEAT
ENPVFARSTV VHPEPRHHPP PNPRQQPHRD SGSLPPGRPG QQPRRDPSRE GSRPPPYRPR
RDAFEISTEG HSGPSHRDRA GPRGARSHNP RHSAFTTTGG SAPGYCQPIT TVTASASVTV
AVHPPPAPGS SRNPRGGLCP GYEGYPETDP GLFEDPHVPF NVRCERRDSK VEVIELQDVE
CEERPRGSGS N
//
