ID I3LVP6_PIG Unreviewed; 966 AA.
AC I3LVP6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Ankyrin repeat and LEM domain containing 2 {ECO:0000313|Ensembl:ENSSSCP00000028199.3};
GN Name=ANKLE2 {ECO:0000313|Ensembl:ENSSSCP00000028199.3,
GN ECO:0000313|VGNC:VGNC:85318};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028199.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000028199.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028199.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000028199.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ANKLE2 family.
CC {ECO:0000256|ARBA:ARBA00007597}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3LVP6; -.
DR SMR; I3LVP6; -.
DR STRING; 9823.ENSSSCP00000028199; -.
DR PaxDb; 9823-ENSSSCP00000028199; -.
DR Ensembl; ENSSSCT00000031796.4; ENSSSCP00000028199.3; ENSSSCG00000026781.4.
DR VGNC; VGNC:85318; ANKLE2.
DR eggNOG; ENOG502QQ4Z; Eukaryota.
DR GeneTree; ENSGT00390000016767; -.
DR HOGENOM; CLU_534801_0_0_1; -.
DR InParanoid; I3LVP6; -.
DR TreeFam; TF317729; -.
DR Reactome; R-SSC-2995383; Initiation of Nuclear Envelope (NE) Reformation.
DR Reactome; R-SSC-9013404; RAC2 GTPase cycle.
DR Reactome; R-SSC-9013408; RHOG GTPase cycle.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000026781; Expressed in ovary and 44 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0007084; P:mitotic nuclear membrane reassembly; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IBA:GO_Central.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central.
DR CDD; cd12944; LEM_ANKL2; 1.
DR Gene3D; 1.10.720.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR InterPro; IPR035006; LEM_ANKL2.
DR InterPro; IPR003887; LEM_dom.
DR InterPro; IPR011320; RNase_H1_N.
DR InterPro; IPR037056; RNase_H1_N_sf.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01693; Cauli_VI; 1.
DR Pfam; PF03020; LEM; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF63451; LEM domain; 1.
DR PROSITE; PS50954; LEM; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..117
FT /note="LEM"
FT /evidence="ECO:0000259|PROSITE:PS50954"
FT REGION 702..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 105671 MW; C9237DAD53CB5EB2 CRC64;
MLWPRLAAAE WAALAWELLG ASVLLIAVRW LVRRLDRRPR VLGRSGPPDP LPCASAAPFP
DPGLGEMTMD TILARLKLLN PDDLREEILK AGLKCGPITS TTRFIFEKKL AQALLEHSTL
PSHPSDHDAT GATVLGQDTR RIMKSAVGSP AEQVSFSEDR DFGYSVGLNP PEEDAMTSET
CSVPFSASAG VSSHKAMLRA SAEPPLYYGV CPAYEDALAR NERIHVYEDK KEALQAVKMI
KGSRFKAFTS REDAEKFARG ICDYFPSPSK TSLPLSPVKM TPLFSNDGLY LSESEAANRE
RANSYKNPRT QDLTAKLRRA VEKGEEDTFS DLIWSNPRYL IGSGDNPTIV QEGCRYNVLH
VAAKENQAAL CQLTLETLEN PEFMRLMYPD DEPHMLEKRI CYVLDLYLNT PDRVGYDTPL
HFACKFGNAD VVNVLSSHPL IVKNPRNKYD KTPEDVICER SKNKSMELKE RIRDYLKGHY
YVPLLRAEDT SSPVIGELWS SDQTGEASHI GYSGGGPRDP VLTLRAFAGP LSPSKAEDFR
RLWKTPPREK AGFFHSVRKS DPDRGIERVG RELAHELGYP WVEYWDFLGC FVDLSSQAGL
QKLEEYLTQQ EVGKKPQQDM GENSACRQED TSALGRHRKG SNSISVGAFL DEDEDVSLEE
IKNRQNIARS STQPAVTASR ASGCNIHPSE QKSELIEASA PTIPHSNKNG FCSPLSEGKT
LGGKRPKAPV GEEAFLSPVS GLTVEFDKLN LQNLESSFSK TPKKNSKTQE KILASGVSAE
GDGSGLPAAD PPGETQMRTE SEMSAGISNL YLGPTSPRLA AQQSCGSVTS GPSGVNASQD
PVQRRFLSGE EPSKLDRDVL AALENADVDP QQYPAVNRWK SAVLGFSPSD RQSWPSPATK
GKWKSQLLDL GGPPLSSPGR SSPTVGSPVK PGPAPHSPGL GSPGRYSPAN GGQLRRMARL
AQLATL
//