ID I3LVV9_ICTTR Unreviewed; 307 AA.
AC I3LVV9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=SEC22 homolog A, vesicle trafficking protein {ECO:0000313|Ensembl:ENSSTOP00000000036.3};
GN Name=SEC22A {ECO:0000313|Ensembl:ENSSTOP00000000036.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000000036.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000000036.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000256|ARBA:ARBA00003595}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00008025}.
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DR EMBL; AGTP01099803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01099804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01099805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01099806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01099807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013220022.1; XM_013364568.1.
DR AlphaFoldDB; I3LVV9; -.
DR STRING; 43179.ENSSTOP00000000036; -.
DR Ensembl; ENSSTOT00000000042.3; ENSSTOP00000000036.3; ENSSTOG00000000042.3.
DR GeneID; 101978060; -.
DR CTD; 26984; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000158470; -.
DR HOGENOM; CLU_054453_0_0_1; -.
DR InParanoid; I3LVV9; -.
DR OrthoDB; 129635at2759; -.
DR TreeFam; TF105933; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14824; Longin; 1.
DR Gene3D; 3.30.450.50; Longin domain; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; LONGIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46258:SF3; VESICLE-TRAFFICKING PROTEIN SEC22A; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000259|PROSITE:PS50859"
SQ SEQUENCE 307 AA; 35010 MW; E83F396B154FC7B1 CRC64;
MSVILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR CTLKTGHYNI
NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ
RTKQRYNNPR SLSTKINLSD MQMEIKLRPP YQIPMCELGS ANGVTSAFSV DYKGAGKISS
AHQRLEPATL SGIVAFILSL LCGALNLIRG FHAIESLLQS DGEDFNYIIA FFLGTAACLY
QCYLLVYYTG WRNVKSFLTL GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG
KAPDYDV
//
