ID I3LW33_ICTTR Unreviewed; 945 AA.
AC I3LW33;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=BicC family RNA binding protein 1 {ECO:0000313|Ensembl:ENSSTOP00000000148.3};
GN Name=BICC1 {ECO:0000313|Ensembl:ENSSTOP00000000148.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000000148.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000000148.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BicC family.
CC {ECO:0000256|ARBA:ARBA00007662}.
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DR EMBL; AGTP01076870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01076878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3LW33; -.
DR STRING; 43179.ENSSTOP00000000148; -.
DR Ensembl; ENSSTOT00000000168.3; ENSSTOP00000000148.3; ENSSTOG00000000168.3.
DR eggNOG; KOG4374; Eukaryota.
DR GeneTree; ENSGT00940000156276; -.
DR HOGENOM; CLU_847209_0_0_1; -.
DR InParanoid; I3LW33; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd22420; KH-I_BICC1_rpt1; 1.
DR CDD; cd22421; KH-I_BICC1_rpt2; 1.
DR CDD; cd22422; KH-I_BICC1_rpt3; 1.
DR CDD; cd09520; SAM_BICC1; 1.
DR Gene3D; 3.30.310.270; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR047549; BICC1_KH-I_rpt1.
DR InterPro; IPR047554; BICC1_KH-I_rpt2.
DR InterPro; IPR047553; BICC1_KH-I_rpt3.
DR InterPro; IPR037974; BICC1_SAM_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR10627:SF78; PROTEIN BICAUDAL C HOMOLOG 1; 1.
DR PANTHER; PTHR10627; SCP160; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00322; KH; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 844..907
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 563..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 101916 MW; 4E2C9F50A646785C CRC64;
GSEDDLVAGA PLHSPEWSEE RFRVDRKKLE AMLQAAAEGK GRSGEDFFQK IMEETNTQIA
WPSKLKIGAK SKKDPHIKVS GKKEDVKEAK EMIMSVLDTK SNRVTLKMDV SHTEHSHVIG
KGGNNIKKVM EETGCHIHFP DSNRNNQAEK SNQVSIAGQP AGVESARVRI RELLPLVLMF
ELPIAGILQP VPDPNSPSIQ HISQTYNISV SFKQRSRMYG ATVIVRGSQN NTSAVKEGTA
MLLEHLAGSL ASAIPVSTQL DIAAQHHLFM MGRNGSNIKH IMQRTGAQIH FPDPSNPQKK
STVYLQGTIE SVCLARQYLM GCLPLVLMFD MKEEIEVDPQ FIAQLMEQLD VFISIKPKPK
QPSKSVIVKS VERNALNMYE ARKCLLGLES SGVTIATSSS PASCPAGLAC PSLDILASAG
LGLTGLGLLG PTALSLNTST NPNSLLNALN SSVSPLQSPS SGTPSPTLWA PPLANTSSAT
GFSAIPHLMI PSTAQATLTN ILLSGVPTYG HTAPSPPPGL TPVDVHINSM QTEGKKITAS
LNGHAQSPNI KYGAISTSSL GEKVLSGNHG DPSIQTTGSE QASPKSNPSE GCNDAFVEVG
MPRSPSHSGN AGDLKQMMGH SKVSCAKRQT VELLQGTKNS HLHSTDRLLS DPELSAAESP
VADKKAPGSE RAAERAAAAQ QNSERARLAP RPSYINMQAF DYEQKKLLAT KAMLKKPVVT
EVRTPTNTWS GLGFSKSMPA ETIKELRRAN HVSYKPTMTT TYEGSSVSLS RSNSREHLGS
GSESDNWRDR NGIGPASHSE FAASASSPKR KQNKSTEHYL SSSNYMDCIS SLTGSNGCNL
SSSFKGSDLP ELFSKLGLGK YTDVFQQQEI DLQTFLTLTD QDLKELGITT FGARRKMLLA
ISELNKNRRK LFEPPNARTS FLEGGASGRL PRQYHSDMAS VSGRW
//
