ID I3LWW2_ICTTR Unreviewed; 761 AA.
AC I3LWW2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Zinc finger and BTB domain containing 49 {ECO:0000313|Ensembl:ENSSTOP00000000499.2};
GN Name=ZBTB49 {ECO:0000313|Ensembl:ENSSTOP00000000499.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000000499.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000000499.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AGTP01011582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005319028.1; XM_005318971.2.
DR AlphaFoldDB; I3LWW2; -.
DR STRING; 43179.ENSSTOP00000000499; -.
DR Ensembl; ENSSTOT00000000552.3; ENSSTOP00000000499.2; ENSSTOG00000000550.3.
DR GeneID; 101957300; -.
DR CTD; 166793; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158750; -.
DR HOGENOM; CLU_018392_0_0_1; -.
DR InParanoid; I3LWW2; -.
DR OMA; AVYGPYV; -.
DR OrthoDB; 5295767at2759; -.
DR TreeFam; TF330993; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001223; F:transcription coactivator binding; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR CDD; cd18233; BTB_POZ_ZBTB49; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24394:SF45; ZINC FINGER PROTEIN 771; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 25..91
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 391..418
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 419..446
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 447..474
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 475..502
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 503..530
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 531..558
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 559..586
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 171..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 84288 MW; 507B3ABF6F2975D5 CRC64;
MDPVAAHSCH LLQQLHEQRI QGLLCDCMLV VRGVCFKAHK NVLAAFSQYF RSLFQNSSSQ
KNDVFHLDVK NISGIGQILD FMYTSHLDLN PDNIQVMLDT AQCLQVQNVL DLCHTFLKSA
SEQPPGMPCD STFSLQSTLA PDATCVMNEN YPHLLQECPA GTQHAKVLDE PHPHAPSVSL
HHSTGEMSKQ APSALDSSCS ELPCKQPSYY YKLRDFYSKQ YCKQAACPSQ ERGTEQPFAF
TSPTDLAAVD SQSCAISHSE CLLESSEHLP STFLAQPPSD SIPDPESDAP GQQPTKQMRL
KKAIHLKKLN FLKSQKLTEQ ASEHKLDYGL TKKTESAREN MAEEASSRST EEKESEDISS
ENFNCVSEME LSEAPATLED QSQSLHSQRQ YACELCGKPF KHPSNLELHK RSHTGEKPFE
CNICGKHFSQ AGNLQTHLRR HSGEKPYICE ICGKRFAASG DVQRHIIIHS GEKPHLCDTC
GRGFSNFSNL KEHKKTHTAD KVFTCDQCGK SFNMQRKLVK HRVRHTGERP YSCSACGKCF
GGSGDLRRHV RTHTGEKPYT CEICGKCFTR SAVLRRHRKM HCRADAESPG VLEELGRALE
TSDLERSQSS DSFSQDVSVA LMPVSVKLPV HPVGNSTTEF DSQSAGSYCK LHSMIPPPGA
SAQEKLSLDA VKLAKPQVPQ AQPQAYTYPD MDTPASSEPL QADSTAMVRS SLAALDNHCP
DPLGGRASST AYRNSEGQFF SSMTLWGLAM KTLQNENELD Q
//
