ID   I3LX08_ICTTR            Unreviewed;       378 AA.
AC   I3LX08;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 4 {ECO:0000256|ARBA:ARBA00014934};
DE   AltName: Full=26S proteasome regulatory subunit RPN10 {ECO:0000256|ARBA:ARBA00044341};
GN   Name=PSMD4 {ECO:0000313|Ensembl:ENSSTOP00000000551.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000000551.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000000551.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5A family.
CC       {ECO:0000256|ARBA:ARBA00005574}.
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DR   EMBL; AGTP01066249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3LX08; -.
DR   STRING; 43179.ENSSTOP00000000551; -.
DR   Ensembl; ENSSTOT00000000606.3; ENSSTOP00000000551.3; ENSSTOG00000000605.3.
DR   GeneTree; ENSGT00530000064050; -.
DR   HOGENOM; CLU_033293_0_1_1; -.
DR   InParanoid; I3LX08; -.
DR   TreeFam; TF106232; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0022624; C:proteasome accessory complex; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   CDD; cd22297; PSMD4_RAZUL; 1.
DR   CDD; cd01452; VWA_26S_proteasome_subunit; 1.
DR   Gene3D; 6.10.250.380; -; 1.
DR   Gene3D; 6.10.300.40; -; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR049590; PSMD4_RAZUL-like.
DR   InterPro; IPR003903; UIM_dom.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10223; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR   PANTHER; PTHR10223:SF0; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; 1.
DR   Pfam; PF02809; UIM; 2.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00726; UIM; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50330; UIM; 2.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          6..189
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          225..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   378 AA;  40898 MW;  A1218143FAAB22B9 CRC64;
     HHIPTKMLCP VDNSEYMRNG DFLPTRLQAQ QDAVNIVCHS KTRSNPENNV GLITLANDCE
     VLTTLTPDTG RILSKLHTVQ PKGKITFCTG IRVAHLALKH RQGKNHKMRI IAFVGSPVED
     NEKDLVKLAK RLKKEKVNVD IINFGEEEVN TEKLTAFVNT LNGKDGTGSH LVTVPPGPSL
     ADALISSPIL AGEGGAMLGL GASDFEFGVD PSADPELALA LRVSMEEQRQ RQEEEARRAA
     AASAAEAGIA TAGTEDSDDA LLKMTISQQE FGRTGLPDLS SMTEEEQIAY AMQMSLQGAE
     FGQAESADLD ANSAMDTSEP AKEEDDYDVM QDPEFLQSVL ENLPGVDPNN EAIRNAMGSL
     ASQATKDGKK DKKEEDKK
//