ID I3LY45_ICTTR Unreviewed; 1165 AA.
AC I3LY45;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Scavenger receptor cysteine-rich type 1 protein M130-like {ECO:0000313|Ensembl:ENSSTOP00000001058.3};
GN Name=CD163 {ECO:0000313|Ensembl:ENSSTOP00000001058.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001058.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001058.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01113243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3LY45; -.
DR STRING; 43179.ENSSTOP00000001058; -.
DR Ensembl; ENSSTOT00000001183.3; ENSSTOP00000001058.3; ENSSTOG00000001180.3.
DR eggNOG; ENOG502QQ5W; Eukaryota.
DR GeneTree; ENSGT00940000155987; -.
DR HOGENOM; CLU_002555_0_2_1; -.
DR InParanoid; I3LY45; -.
DR TreeFam; TF329295; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR Gene3D; 3.10.250.10; SRCR-like domain; 9.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF15; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 9.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 9.
DR SUPFAM; SSF56487; SRCR-like; 9.
DR PROSITE; PS00420; SRCR_1; 4.
DR PROSITE; PS50287; SRCR_2; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1059..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..176
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 183..283
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 290..390
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 397..497
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 502..602
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 607..707
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 743..843
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 848..950
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 953..1053
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 101..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 114..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 145..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 208..272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 221..282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 252..262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 315..379
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 328..389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 359..369
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 422..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 435..496
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 466..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 527..591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 540..601
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 571..581
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 632..696
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 645..706
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 676..686
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 768..832
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 781..842
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 812..822
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 888..949
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 919..929
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 978..1042
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 991..1052
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1022..1032
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 1165 AA; 126689 MW; CE0C2166ECF4513A CRC64;
MFDLRFKSND VIKGQELVNF SGNEPVFKLR RYLLEKVKYV DFRRWLVHLS SITIAVVSLL
SAFFIPTSVE GTEKELRLMA GENNCSGRVE VKIQEEWGTV CNHGWSINEV SVICSQLGCP
TTIKATGWVN STAGSGRIWM DHVSCRGNES ALWDCKHDGW GKHNCTHQQD AGVTCSDGSN
LEMRLMNGGN RCSGRIEVKF QGQWGTVCDD GFNLEHASVV CKQLGCGSAV SFSGSAHFGE
SSGPIWFDDL VCNGTESALW NCRHQGWGKH NCDHAEDVGV ICLDGADLGL RLVDGVTKCS
GRLEVKFQGE WGTVCDDNWD NNDAAVVCKQ LGCPTAITAT GRVNASEGSG NIWLDSVSCH
GHESSLWQCR HHEWGKHYCT HKEDAGVTCS DGSDLELRLI GGGSRCAGTV EVEIQKLLGK
VCGRLWTLNE ANVVCRQLGC GSALQTSFQM YSKIKPTNTW LFVSSCSGNE TSLWDCKNWQ
WGGLLCDHNE EAQITCSAHR EPRLVGGDVP CSGRVEVKHG DTWGSVCDSD FSLEAASVLC
RELECGTVVS IVGGAHFGEG TGQIWAEEFQ CGGHESHLSL CPVVPRPDET CSHSRDVGVV
CSRYVETRLV DGKSSCEGRV ELKVLGIWGS LCNSHWDIED AHVLCQQLKC GVALSTPGGA
PFGKGNGQVW RHMFHCTGTE QHMGDCPVTA LGTLLCSEGQ VASVICSGNQ SQTLSPCNSS
SSDPMSSIIP EESSAACIGS GQLRLVNGGG RCAGRIEIYH EGSWGTICDD SWDLSDAHVV
CRQLDCGVAI NATGSAHFGE GTGPILLDEV NCNGKESHVW QCHSHGWGRH NCRHKEDAGV
ICSEFMSLRL NSETSGETCA GRLEVFYNGT WGSVGRSDMS ATTVGVVCRQ LGCAEKGNIN
PASLDKTPSR LMWVDHVQCP KGPDTLWQCP SSPWKQRLGS PSEEAWITCD NKIRLQEGHT
SCSGRVEVWH GGSWGTVCDD SWDLNDAQVV CQQLGCGKAE KALKEAAFGQ GTGPIWLNQV
KCRGNETSLW DCPAGPWGHT DCGHKEDAAV QCQPGHSSLI ALLILGIILL ASLITFLVFT
LRRRQIRLFT VSTRGENFVH QVQYQEMNSS LEADDLDQLH PSENSNKLHG FNAGGLISVS
KYFSISGIKK GAILRQTENW EFLTQ
//
