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Database: UniProt
Entry: I3LYG8_ICTTR
LinkDB: I3LYG8_ICTTR
Original site: I3LYG8_ICTTR 
ID   I3LYG8_ICTTR            Unreviewed;      1991 AA.
AC   I3LYG8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSSTOP00000001234};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001234, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000001234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000001234}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AGTP01000242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000001234; -.
DR   Ensembl; ENSSTOT00000001376; ENSSTOP00000001234; ENSSTOG00000001367.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3LYG8; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    233    253       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    382    409       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    743    767       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    779    800       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    862    890       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    949    975       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1202   1220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1241   1260       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1272   1295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1316   1344       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1442   1466       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1524   1542       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1554   1572       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1584   1604       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1641   1669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1745   1768       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      135    416       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      488    701       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      752    979       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      989   1196       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1200   1474       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1523   1778       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      406    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1991 AA;  226920 MW;  3AE5F8E5DFB6917B CRC64;
     MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK PNSDLEAGKN
     LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF RFSATSALYI LTPFNPLRKI
     AIKILVHSYP FSILLWMLVS RYTFTGIYTF ESLIKIIARG FCLEDFTFLR DPWNWLDFTV
     ITFAYVTEFV DLGNVSALRT FRVLRALKTI SVIPGLKTIV GALIQSVKKL SDVMILTVFC
     LSVFALIGLQ LFMGNLRNKC VQWPPTNASL EEHTIERNIT VNNNGTLVNE TLFEFDWKSY
     IQDEKYHYFL EGFLDALLCG NSSDAGQCPE GYMCVKAGRN PNYGYTSFDT FSWAFLSLFR
     LMTQDFWENL YQLTLRAAGK TYMIFFVLVI FLGSFYLINL ILAVVAMAYE EQNQATMEEA
     EQKEAEFQQM LEQLKKQQEA AQQAAAATTS EHSREPSAAG RLSDSSSEAS KLSSKSAKER
     RNRRKKRKQK EQSGGEEKDE DEFHKSESEG SIRRKGFPFS IEGNRLTYEK RYSSPHQSLL
     SIRGSLFSPR RNSRTSLFSF RGRAKDVGSE NDFADDEHST FEDNESRRDS LFVPRRHGER
     RNSNLSQTSR SSRMLAVFPA NGKMHSTVDC NGVVSLVGGP SVPTSPVGQL LPEVIIDKPA
     TDDNGTTTET EMRKRRSSSF HVSMDFLEDP SQRQRAMSIA SILTNTVEEL EESRQKCPPC
     WYKFSNIFLI WDCSPYWLKV KHIVNLVVMD PFVDLAITIC IVLNTLFMAM EHYPMTEHFN
     NVLTVGNLVF TGIFTAEMFL KIIAMDPYYY FQEGWNIFDG FIVTLSLVEL GLANVEGLSV
     LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK
     DCVCKIASDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW DCMEVAGQAM CLTVFMMVMV
     IGNLVVLNLF LALLLSSFSA DNLAATDDDN EMNNLQIAVD RMHKGIAYVK RKIYEFIQQS
     FVRKQKILDE IKPLDDLNNK KDSCMSNHTT EIGKDLDYLK DVNGTTSGIG TGSSVEKYII
     DESDYMSFIN NPSLTVTVPI AVGESDFENL NTEDFSSESD LEESKEKLNE SSSSSEGSTV
     DIGAPAEEQP VVEPEETLEP EACFTEGCVQ RFKCCQISVE EGRGKQWWNL RRTCFRIVEH
     NWFETFIVFM ILLSSGALAF EDIYIDQRKT IKTMLEYADK VFTYIFILEM LLKWVAYGYQ
     TYFTNAWCWL DFLIVDVSLV SLTANALGYS ELGAIKSLRT LRALRPLRAL SRFEGMRVVV
     NALLGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYHCV NTTTGDMFEI SEVNNHSDCL
     KLIERNETAR WKNVKVNFDN VGFGYLSLLQ VATFKGWMDI MYAAVDSRNV ELQPKYEESL
     YMYLYFVIFI IFGSFFTLNL FIGVIIDNFN QQKKKISQDI FMTEEQKKYY NAMKKLGSKK
     PQKPIPRPGN KFQGMVFDFV TRQVFDISIM ILICLNMVTM MVETDDQSEY VTNILSRINL
     VFIVLFTGEC VLKLISLRHY YFTIGWNIFD FVVVILSIVG MFLAELIEKY FVSPTLFRVI
     RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG MSNFAYVKRE
     VGIDDMFNFE TFGNSMICLF QITTSAGWDG LLAPILNSKP PDCDPKKDNP GSSVKGDCGN
     PSVGIFFFVS YIIISFLVVV NMYIAVILEN FSVATEESAE PLSEDDFEMF YEVWEKFDPD
     ATQFMEFEKL SQFAAALEPP LNLPQPNKLQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE
     SGEMDALRIQ MEERFMASNP SKVSYQPITT TLKRKQEEVS AVIIQRAYRR HLLKRTVKQA
     SFAYNKNKLK GGANLLVKED MIIDRINENS ITEKTDLTMS TAVCPPSYDR VTKPIVEKHE
     QEGKDEKAKG K
//
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